Document Detail

Physical activity and progression of carotid intima-media thickness in patients with coronary heart disease.
MedLine Citation:
PMID:  18522790     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We conducted the present study to determine the level of physical activity required to retard the progression of carotid intima-media thickness (IMT) in patients with coronary heart disease (CHD).
PATIENTS AND MAIN OUTCOME MEASUREMENTS: The daily walking distance (km/day) of 40 patients with CHD (male/female ratio: 37/3, mean age: 61.2 years, mean interval time after a coronary event 16.2 months) was examined. Carotid IMT examinations (B-mode ultrasonography) were performed at the baseline and after 6 months.
RESULTS: Among the patients, the average walking distance was 4.00km/day. Walking distance was inversely associated with IMT progression (r=-0.51, p<0.01). Multivariate logistic regression analysis revealed that walking distance (p=0.024) is a predictor for IMT progression independent of classical cardiovascular risk factors. Receiver operating characteristic analysis showed that the walking distance of 4.25km was strongly predictive of IMT preservation (sensitivity 64.0%, specificity 73.3%) in CHD patients.
CONCLUSIONS: Our data suggested that an increase in the daily walking distance could retard the progression of carotid IMT in patients with CHD. Cardiology medical staff should encourage their patients to expend an average of 4-5km in daily walking distance for the secondary prevention of cardiovascular disease.
Shinji Sato; Shigeru Makita; Ryusei Uchida; Shunich Ishihara; Mitsuru Majima
Publication Detail:
Type:  Journal Article     Date:  2008-04-21
Journal Detail:
Title:  Journal of cardiology     Volume:  51     ISSN:  1876-4738     ISO Abbreviation:  J Cardiol     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-04     Completed Date:  2011-02-09     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  8804703     Medline TA:  J Cardiol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  157-62     Citation Subset:  IM    
Department of Rehabilitation Medicine, International Medical Center, Saitama Medical University, Hidaka-City, Saitama 350-1298, Japan.
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MeSH Terms
Carotid Arteries / pathology*,  ultrasonography
Coronary Disease / pathology*
Disease Progression
Middle Aged
Motor Activity / physiology*
ROC Curve
Regression Analysis
Tunica Intima / pathology*
Tunica Media / pathology*

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