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Physical activity for patients undergoing an allogeneic hematopoietic stem cell transplantation: benefits of a moderate exercise intervention.
MedLine Citation:
PMID:  21545527     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
An allogeneic hematopoietic stem cell transplantation (HSCT) can have profound and lasting adverse effects on a patient's physical and psychological well- being. So far, only few studies have investigated the effectiveness of physical activity over the entire inpatient phase of an allogeneic HSCT. PURPOSE: We performed a randomized controlled study to examine the influence of a controlled moderate exercise program starting parallel to chemotherapeutic conditioning and total body irradiation on the patient's physical and psychological constitution. PATIENTS AND METHODS: 47 patients undergoing an allogeneic HSCT were randomly assigned to an exercise group (EG) or a control group (CG). While the EG took part in an endurance and ADL-training twice a day the CG received the clinic's standard physiotherapy program once a day. RESULTS: Significant differences and/or trends in favor of the EG were observed regarding the primary endpoint endurance performance (p= 0.002), muscular strength (p= 0.022), fatigue (p= 0.046), and emotional state (p= 0.028) without posing an additional risk for the individual. CONCLUSION: The results show that the training program is feasible and seems to have positive influences on physical performance and quality of life in patients undergoing an allogeneic HSCT. However, further studies are necessary to confirm these results.
Authors:
Freerk T Baumann; Eva M Zopf; Eike Nykamp; Ludwig Kraut; Klaus Schüle; Thomas Elter; Aa Fauser; Wilhelm Bloch
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-4
Journal Detail:
Title:  European journal of haematology     Volume:  -     ISSN:  1600-0609     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703985     Medline TA:  Eur J Haematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 John Wiley & Sons A/S.
Affiliation:
Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sport Medicine, German Sport University Cologne, Germany Saarland-Heilstätten GmbH-Hospital Idar- Oberstein, Germany Department of Hematology and Oncology, University of Cologne.
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