Document Detail


Physical activity is independently associated with multiple measures of arterial stiffness in adolescents and young adults.
MedLine Citation:
PMID:  22153839     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Physical activity (PA) is associated with decreased levels of arterial stiffness in adults, but the relationship between PA and multiple measures of arterial stiffness in adolescents and young adults is not clear. The objective of this study was to test the hypothesis that PA is an independent predictor of multiple measures of arterial stiffness in adolescents and young adults. A total of 548 participants were enrolled in a study of the cardiovascular effects of obesity and type 2 diabetes mellitus (T2DM) (lean, 201; obese, 191; T2DM, 156). Anthropometrics, blood pressure, central and peripheral measures of arterial stiffness (pulse wave velocity, brachial distensibility, and augmentation index), blood (lipids and metabolic tests), and accelerometry data were collected. General linear modeling was performed to test for the independent relationship of PA on arterial stiffness. The mean age of the participants was 17.9 years (standard deviation, 3.5 years). After adjusting for other cardiovascular disease risk factors such as age, sex, body size, mean arterial pressure, and the presence of obesity or T2DM, PA was an independent predictor of augmentation index and brachial distensibility (P < .001). A greater effect of PA on pulse wave velocity was found in participants with T2DM (P = .009) compared with participants in the lean or obese groups. Physical activity is significantly and independently associated with multiple measures of arterial stiffness in adolescents and young adults. The role of PA in the prevention of cardiovascular disease target organ damage in youth, independent of energy balance, merits further exploration.
Authors:
Nicholas M Edwards; Stephen R Daniels; Randall P Claytor; Philip R Khoury; Lawrence M Dolan; Thomas R Kimball; Elaine M Urbina
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-12-06
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  61     ISSN:  1532-8600     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-28     Completed Date:  2012-08-01     Revised Date:  2014-11-13    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  United States    
Other Details:
Languages:  eng     Pagination:  869-72     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Blood Pressure / physiology
Brachial Artery / physiopathology
Diabetes Mellitus, Type 2 / complications,  physiopathology*
Exercise / physiology*
Female
Humans
Male
Obesity / complications,  physiopathology*
Pulsatile Flow / physiology
Vascular Resistance / physiology
Vascular Stiffness / physiology*
Young Adult
Grant Support
ID/Acronym/Agency:
KL2 RR026315/RR/NCRR NIH HHS; KL2 RR026315-03/RR/NCRR NIH HHS; KL2 TR000078/TR/NCATS NIH HHS; KL2RR026315/RR/NCRR NIH HHS; P30 DK048520/DK/NIDDK NIH HHS; R01 HL076269-04/HL/NHLBI NIH HHS; R01 HL105591/HL/NHLBI NIH HHS; R01HL076269/HL/NHLBI NIH HHS; UL1 RR026314/RR/NCRR NIH HHS; UL1 RR026314/RR/NCRR NIH HHS; UL1 RR026314-03/RR/NCRR NIH HHS; UL1 TR000077/TR/NCATS NIH HHS
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