| Physical activity is independently associated with multiple measures of arterial stiffness in adolescents and young adults. | |
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MedLine Citation:
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PMID: 22153839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Physical activity (PA) is associated with decreased levels of arterial stiffness in adults, but the relationship between PA and multiple measures of arterial stiffness in adolescents and young adults is not clear. The objective of this study was to test the hypothesis that PA is an independent predictor of multiple measures of arterial stiffness in adolescents and young adults. A total of 548 participants were enrolled in a study of the cardiovascular effects of obesity and type 2 diabetes mellitus (T2DM) (lean, 201; obese, 191; T2DM, 156). Anthropometrics, blood pressure, central and peripheral measures of arterial stiffness (pulse wave velocity, brachial distensibility, and augmentation index), blood (lipids and metabolic tests), and accelerometry data were collected. General linear modeling was performed to test for the independent relationship of PA on arterial stiffness. The mean age of the participants was 17.9 years (standard deviation, 3.5 years). After adjusting for other cardiovascular disease risk factors such as age, sex, body size, mean arterial pressure, and the presence of obesity or T2DM, PA was an independent predictor of augmentation index and brachial distensibility (P < .001). A greater effect of PA on pulse wave velocity was found in participants with T2DM (P = .009) compared with participants in the lean or obese groups. Physical activity is significantly and independently associated with multiple measures of arterial stiffness in adolescents and young adults. The role of PA in the prevention of cardiovascular disease target organ damage in youth, independent of energy balance, merits further exploration. |
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Authors:
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Nicholas M Edwards; Stephen R Daniels; Randall P Claytor; Philip R Khoury; Lawrence M Dolan; Thomas R Kimball; Elaine M Urbina |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-12-06 |
Journal Detail:
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Title: Metabolism: clinical and experimental Volume: 61 ISSN: 1532-8600 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-05-28 Completed Date: 2012-08-01 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0375267 Medline TA: Metabolism Country: United States |
Other Details:
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Languages: eng Pagination: 869-72 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Cincinnati Children's Hospital Medical Center and University of Cincinnati, Department of Pediatrics, Cincinnati, OH, USA. nicholas.edwards@cchmc.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Blood Pressure / physiology Brachial Artery / physiopathology Diabetes Mellitus, Type 2 / complications, physiopathology* Exercise / physiology* Female Humans Male Obesity / complications, physiopathology* Pulsatile Flow / physiology Vascular Resistance / physiology Vascular Stiffness / physiology* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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KL2 RR026315/RR/NCRR NIH HHS; KL2 TR000078/TR/NCATS NIH HHS; KL2RR026315/RR/NCRR NIH HHS; R01 HL105591/HL/NHLBI NIH HHS; R01HL076269/HL/NHLBI NIH HHS; UL1 RR026314/RR/NCRR NIH HHS; UL1 RR026314/RR/NCRR NIH HHS; UL1 TR000077/TR/NCATS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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