Document Detail


Physical activity in relation to cancer of the colon and rectum in a cohort of male smokers.
MedLine Citation:
PMID:  11303597     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined the association between occupational and leisure physical activity and colorectal cancer in a cohort of male smokers. Among the 29,133 men aged 50-69 years in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention study,152 colon and 104 rectal cancers were documented during up to 12 years of follow-up. For colon cancer, compared with sedentary workers, men in light occupational activity had a relative risk (RR) of 0.60 [95% confidence interval (CI), 0.34-1.04], whereas those in moderate/heavy activity had an RR of 0.45 (CI, 0.26-0.78; P for trend, 0.003). Subsite analysis revealed a significant association for moderate/heavy occupational activity in the distal colon (RR, 0.21; CI, 0.09-0.51) but not in the proximal colon (RR, 0.87; CI, 0.40-1.92). There was no significant association between leisure activity and colon cancer (active versus sedentary; RR, 0.82; CI, 0.59-1.13); however, the strongest inverse association was found among those most active in both work and leisure (RR, 0.33; CI, 0.16-0.71). For rectal cancer, there were risk reductions for those in light (RR, 0.71; CI, 0.36-1.37) and moderate/heavy occupational activity (RR, 0.50; CI, 0.26-0.97; P for trend, 0.04), and no association for leisure activity. These data provide evidence for a protective role of physical activity in colon and rectal cancer.
Authors:
L H Colbert; T J Hartman; N Malila; P J Limburg; P Pietinen; J Virtamo; P R Taylor; D Albanes
Related Documents :
21685477 - Prostate cancer diagnosis in a resource-poor setting: the changing role of digital rect...
14994117 - Pneumomediastinum, pneumopericardium, and pneumoperitoneum caused by peridiverticulitis...
9421877 - Two groups of endogenous mmtv related retroviral env transcripts expressed in human tis...
11156377 - 15-lipoxygenase-1 mediates nonsteroidal anti-inflammatory drug-induced apoptosis indepe...
16470807 - Fish consumption and breast cancer risk. the european prospective investigation into ca...
18298317 - I-131 accumulation in a benign cystic mesothelioma in a patient with follicular thyroid...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology     Volume:  10     ISSN:  1055-9965     ISO Abbreviation:  Cancer Epidemiol. Biomarkers Prev.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-04-16     Completed Date:  2001-09-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9200608     Medline TA:  Cancer Epidemiol Biomarkers Prev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  265-8     Citation Subset:  IM    
Affiliation:
Division of Clinical Sciences, National Cancer Institute, NIH, Bethesda, Maryland 20892-7058, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Age Distribution
Aged
Cohort Studies
Colonic Neoplasms / diagnosis,  epidemiology*
Comorbidity
Confidence Intervals
Confounding Factors (Epidemiology)
Exercise*
Finland / epidemiology
Health Behavior
Humans
Incidence
Life Style*
Male
Middle Aged
Probability
Prognosis
Rectal Neoplasms / diagnosis,  epidemiology*
Risk Assessment
Risk Factors
Smoking / epidemiology*
Grant Support
ID/Acronym/Agency:
N01 CN 45165/CN/NCI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Nicotine metabolism and CYP2D6 phenotype in smokers.
Next Document:  Phase I/pharmacodynamic study of N-acetylcysteine/oltipraz in smokers: early termination due to exce...