Document Detail

Physical activity in relation to cancer of the colon and rectum in a cohort of male smokers.
MedLine Citation:
PMID:  11303597     Owner:  NLM     Status:  MEDLINE    
We examined the association between occupational and leisure physical activity and colorectal cancer in a cohort of male smokers. Among the 29,133 men aged 50-69 years in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention study,152 colon and 104 rectal cancers were documented during up to 12 years of follow-up. For colon cancer, compared with sedentary workers, men in light occupational activity had a relative risk (RR) of 0.60 [95% confidence interval (CI), 0.34-1.04], whereas those in moderate/heavy activity had an RR of 0.45 (CI, 0.26-0.78; P for trend, 0.003). Subsite analysis revealed a significant association for moderate/heavy occupational activity in the distal colon (RR, 0.21; CI, 0.09-0.51) but not in the proximal colon (RR, 0.87; CI, 0.40-1.92). There was no significant association between leisure activity and colon cancer (active versus sedentary; RR, 0.82; CI, 0.59-1.13); however, the strongest inverse association was found among those most active in both work and leisure (RR, 0.33; CI, 0.16-0.71). For rectal cancer, there were risk reductions for those in light (RR, 0.71; CI, 0.36-1.37) and moderate/heavy occupational activity (RR, 0.50; CI, 0.26-0.97; P for trend, 0.04), and no association for leisure activity. These data provide evidence for a protective role of physical activity in colon and rectal cancer.
L H Colbert; T J Hartman; N Malila; P J Limburg; P Pietinen; J Virtamo; P R Taylor; D Albanes
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology     Volume:  10     ISSN:  1055-9965     ISO Abbreviation:  Cancer Epidemiol. Biomarkers Prev.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-04-16     Completed Date:  2001-09-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9200608     Medline TA:  Cancer Epidemiol Biomarkers Prev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  265-8     Citation Subset:  IM    
Division of Clinical Sciences, National Cancer Institute, NIH, Bethesda, Maryland 20892-7058, USA.
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MeSH Terms
Age Distribution
Cohort Studies
Colonic Neoplasms / diagnosis,  epidemiology*
Confidence Intervals
Confounding Factors (Epidemiology)
Finland / epidemiology
Health Behavior
Life Style*
Middle Aged
Rectal Neoplasms / diagnosis,  epidemiology*
Risk Assessment
Risk Factors
Smoking / epidemiology*
Grant Support

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