Document Detail

Physical activity, exercise, and inflammatory markers in older adults: findings from the Health, Aging and Body Composition Study.
MedLine Citation:
PMID:  15209647     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To examine the association between physical activity and inflammatory markers, with consideration for body fatness and antioxidant use. DESIGN: Cross-sectional study, using baseline data from the Health, Aging and Body Composition Study. SETTING: Metropolitan areas surrounding Pittsburgh, Pennsylvania, and Memphis, Tennessee. PARTICIPANTS: Black and white, well-functioning men and women (N=3,075), aged 70 to 79. MEASUREMENTS: Interviewer-administered questionnaires of previous-week household, walking, exercise, and occupational/volunteer physical activities. Analysis of covariance was used to examine the association between activity level and serum C-reactive protein (CRP), interleukin-6 (IL-6), and plasma tumor necrosis factor alpha (TNFalpha) with covariate adjustment. Antioxidant supplement use (multivitamin, vitamins E or C, beta carotene) was evaluated as an effect modifier of the association. RESULTS: Higher levels of exercise were associated with lower levels of CRP (P<.01), IL-6 (P<.001), and TNFalpha (P=.02) (e.g., CRP=1.95 mg/L for no exercise and 1.72 for >180 min/wk). Adjustment for body fatness attenuated the associations somewhat. Use of antioxidant supplements modified the CRP (P(interaction)=.01) and IL-6 (P(interaction)=.08) associations such that concentrations were low in those taking supplements (e.g., CRP=1.79-1.84 across exercise levels) and higher in nonsupplement users who did no exercise (2.03) than in those who did the most (1.72). Among nonexercisers, higher levels of other physical activity were related to lower levels of CRP (P<.01) and IL-6 (P=.02) but not TNFalpha (P=.36), even after accounting for body fat. CONCLUSION: Inflammatory markers are lower in older adults with higher levels of exercise and nonexercise activity and in antioxidant supplement users regardless of exercise level.
Lisa H Colbert; Marjolein Visser; Eleanor M Simonsick; Russell P Tracy; Anne B Newman; Stephen B Kritchevsky; Marco Pahor; Dennis R Taaffe; Jennifer Brach; Susan Rubin; Tamara B Harris
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the American Geriatrics Society     Volume:  52     ISSN:  0002-8614     ISO Abbreviation:  J Am Geriatr Soc     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-06-22     Completed Date:  2005-04-05     Revised Date:  2008-03-10    
Medline Journal Info:
Nlm Unique ID:  7503062     Medline TA:  J Am Geriatr Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1098-104     Citation Subset:  IM    
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA.
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MeSH Terms
Aging / physiology*
Antioxidants / administration & dosage
Biological Markers / blood*
Body Composition
C-Reactive Protein / metabolism
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Exercise / physiology*
Geriatric Assessment
Inflammation / blood
Interleukin-6 / blood
Least-Squares Analysis
Physical Fitness*
Tumor Necrosis Factor-alpha / metabolism
Grant Support
N01-AG-6-2101/AG/NIA NIH HHS; N01-AG-6-2103/AG/NIA NIH HHS; N01-AG-6-2106/AG/NIA NIH HHS
Reg. No./Substance:
0/Antioxidants; 0/Biological Markers; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 9007-41-4/C-Reactive Protein

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