Document Detail


Physical activity and exercise in the regulation of human adipose tissue physiology.
MedLine Citation:
PMID:  22298655     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Physical activity and exercise are key components of energy expenditure and therefore of energy balance. Changes in energy balance alter fat mass. It is therefore reasonable to ask: What are the links between physical activity and adipose tissue function? There are many complexities. Physical activity is a multifaceted behavior of which exercise is just one component. Physical activity influences adipose tissue both acutely and in the longer term. A single bout of exercise stimulates adipose tissue blood flow and fat mobilization, resulting in delivery of fatty acids to skeletal muscles at a rate well-matched to metabolic requirements, except perhaps in vigorous intensity exercise. The stimuli include adrenergic and other circulating factors. There is a period following an exercise bout when fatty acids are directed away from adipose tissue to other tissues such as skeletal muscle, reducing dietary fat storage in adipose. With chronic exercise (training), there are changes in adipose tissue physiology, particularly an enhanced fat mobilization during acute exercise. It is difficult, however, to distinguish chronic "structural" changes from those associated with the last exercise bout. In addition, it is difficult to distinguish between the effects of training per se and negative energy balance. Epidemiological observations support the idea that physically active people have relatively low fat mass, and intervention studies tend to show that exercise training reduces fat mass. A much-discussed effect of exercise versus calorie restriction in preferentially reducing visceral fat is not borne out by meta-analyses. We conclude that, in addition to the regulation of fat mass, physical activity may contribute to metabolic health through beneficial dynamic changes within adipose tissue in response to each activity bout.
Authors:
Dylan Thompson; Fredrik Karpe; Max Lafontan; Keith Frayn
Related Documents :
14628645 - Assessment of bronchodilator response through changes in lung volumes in chronic airflo...
18987095 - Exercise stress echocardiography is superior to rest echocardiography in predicting lef...
22301835 - Metabolic regulation of fat use during exercise and in recovery.
17068875 - Effects of rest and exercise on cardiac blood volume determinations.
17583795 - A 10-s sprint performed prior to moderate-intensity exercise prevents early post-exerci...
22327025 - Exercise dependence of n-terminal pro-brain natriuretic peptide in patients with precap...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiological reviews     Volume:  92     ISSN:  1522-1210     ISO Abbreviation:  Physiol. Rev.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-02-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0231714     Medline TA:  Physiol Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  157-91     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Regulation and function of the FGF23/klotho endocrine pathways.
Next Document:  Fast synaptic inhibition in spinal sensory processing and pain control.