| Physical activity during daily life and brachial artery flow-mediated dilation in peripheral arterial disease. | |
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MedLine Citation:
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PMID: 19651668 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We determined whether higher levels of physical activity in daily life are associated with better brachial artery flow-mediated dilation (FMD) among individuals with lower extremity peripheral arterial disease (PAD). Participants were 111 men and women with PAD (ankle-brachial index (ABI) <or= 0.95) who completed baseline testing in the Study to Improve Leg Circulation (SILC). We evaluated FMD of the brachial artery at baseline and at 60 seconds following 4 minutes of suprasystolic blood pressure cuff inflation. Physical activity was measured continuously over 7 days using a vertical accelerometer (Caltrac) and a pedometer (Digiwalker). Adjusting for age, sex, race, ABI, cardiovascular risk factors and other potential confounders, higher levels of physical activity were associated with a greater percent change in brachial artery FMD at 60 seconds post cuff deflation for both Caltrac (1st tertile of activity +4.81% change; 2nd tertile +4.60% change; 3rd tertile +7.23% change; p-trend = 0.018) and the Digiwalker (1st tertile of activity +3.76% change; 2nd tertile +6.25% change; 3rd tertile +7.25% change; p-trend = 0.001). Similar findings were observed for absolute change in brachial artery FMD 60 seconds after cuff deflation. In conclusion, higher levels of physical activity during daily life are associated significantly and independently with better brachial artery FMD among individuals with PAD, even after adjusting for confounders. |
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Authors:
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Laila Payvandi; Alan Dyer; David McPherson; Philip Ades; James Stein; Kiang Liu; Luigi Ferrucci; Michael H Criqui; Jack M Guralnik; Donald Lloyd-Jones; Melina R Kibbe; Susan T Liang; Bonnie Kane; William H Pearce; Michael Verta; Walter J McCarthy; Joseph R Schneider; Adhir Shroff; Mary M McDermott |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Vascular medicine (London, England) Volume: 14 ISSN: 1358-863X ISO Abbreviation: Vasc Med Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-08-04 Completed Date: 2009-10-08 Revised Date: 2013-06-02 |
Medline Journal Info:
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Nlm Unique ID: 9610930 Medline TA: Vasc Med Country: England |
Other Details:
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Languages: eng Pagination: 193-201 Citation Subset: IM |
Affiliation:
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Northwestern University Feinberg School of Medicine, Chicago, IL, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00106327 |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Activities of Daily Living* Aged Aged, 80 and over Brachial Artery / physiopathology*, ultrasonography Cross-Sectional Studies Female Humans Hyperemia / physiopathology Lower Extremity / blood supply* Male Middle Aged Monitoring, Ambulatory / instrumentation Peripheral Vascular Diseases / physiopathology*, therapy*, ultrasonography Recovery of Function Regional Blood Flow Resistance Training* Time Factors Treatment Outcome Ultrasonography, Doppler United States Vasodilation* Walking* |
| Grant Support | |
ID/Acronym/Agency:
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R01-HL073351/HL/NHLBI NIH HHS; Z01 AG000015-50/AG/NIA NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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