Document Detail

Physical activity during daily life and brachial artery flow-mediated dilation in peripheral arterial disease.
MedLine Citation:
PMID:  19651668     Owner:  NLM     Status:  MEDLINE    
We determined whether higher levels of physical activity in daily life are associated with better brachial artery flow-mediated dilation (FMD) among individuals with lower extremity peripheral arterial disease (PAD). Participants were 111 men and women with PAD (ankle-brachial index (ABI) <or= 0.95) who completed baseline testing in the Study to Improve Leg Circulation (SILC). We evaluated FMD of the brachial artery at baseline and at 60 seconds following 4 minutes of suprasystolic blood pressure cuff inflation. Physical activity was measured continuously over 7 days using a vertical accelerometer (Caltrac) and a pedometer (Digiwalker). Adjusting for age, sex, race, ABI, cardiovascular risk factors and other potential confounders, higher levels of physical activity were associated with a greater percent change in brachial artery FMD at 60 seconds post cuff deflation for both Caltrac (1st tertile of activity +4.81% change; 2nd tertile +4.60% change; 3rd tertile +7.23% change; p-trend = 0.018) and the Digiwalker (1st tertile of activity +3.76% change; 2nd tertile +6.25% change; 3rd tertile +7.25% change; p-trend = 0.001). Similar findings were observed for absolute change in brachial artery FMD 60 seconds after cuff deflation. In conclusion, higher levels of physical activity during daily life are associated significantly and independently with better brachial artery FMD among individuals with PAD, even after adjusting for confounders.
Laila Payvandi; Alan Dyer; David McPherson; Philip Ades; James Stein; Kiang Liu; Luigi Ferrucci; Michael H Criqui; Jack M Guralnik; Donald Lloyd-Jones; Melina R Kibbe; Susan T Liang; Bonnie Kane; William H Pearce; Michael Verta; Walter J McCarthy; Joseph R Schneider; Adhir Shroff; Mary M McDermott
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Vascular medicine (London, England)     Volume:  14     ISSN:  1358-863X     ISO Abbreviation:  Vasc Med     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-04     Completed Date:  2009-10-08     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  9610930     Medline TA:  Vasc Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  193-201     Citation Subset:  IM    
Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
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MeSH Terms
Activities of Daily Living*
Aged, 80 and over
Brachial Artery / physiopathology*,  ultrasonography
Cross-Sectional Studies
Hyperemia / physiopathology
Lower Extremity / blood supply*
Middle Aged
Monitoring, Ambulatory / instrumentation
Peripheral Vascular Diseases / physiopathology*,  therapy*,  ultrasonography
Recovery of Function
Regional Blood Flow
Resistance Training*
Time Factors
Treatment Outcome
Ultrasonography, Doppler
United States
Grant Support
R01-HL073351/HL/NHLBI NIH HHS; Z01 AG000015-50/AG/NIA NIH HHS

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