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Physical activity: benefit or weakness in metabolic adaptations in a mouse model of chronic food restriction?
MedLine Citation:
PMID:  25465889     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In restrictive type anorexia nervosa (AN) patients, physical activity is usually associated with food restriction but its physiological consequences remain poorly characterized. In female mice, we evaluated the impact of voluntary physical activity with/without chronic food restriction on metabolic and endocrine parameters that might contribute to AN. In this protocol, FRW mice (i.e. food restriction with running wheel) reached a crucial point of body weight loss (especially fat mass) faster than FR mice (i.e. food restriction only). However, in contrast to FR mice, their body weight stabilized, demonstrating a protective effect of a moderate, regular physical activity. Exercise delayed meal initiation and duration. FRW mice displayed food anticipatory activity compared to FR mice, which was strongly diminished with the prolongation of the protocol. The long-term nature of the protocol enabled assessment of bone parameters, similar to those observed in AN patients. Both restricted groups adapted their energy metabolism differentially in the short and long term, with less fat oxidation in FRW mice and a preferential use of glucose to compensate for the chronic energy imbalance. Finally, like restrictive AN patients, FRW mice exhibited low leptin levels, and high plasma concentrations of corticosterone and ghrelin and a disruption of estrous cycle. In conclusion, our model suggests that physical activity has beneficial effects on the adaptation to the severe condition of food restriction despite the absence of any protective effect on lean and bone mass.
Authors:
Mathieu Méquinion; Emilie Caron; Sarah Zgheib; Alicia Stievenard; Philippe Zizzari; Virginie Tolle; Bernard Cortet; Stéphanie Lucas; Vincent Prevot; Christophe Chauveau; Odile Viltart
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-12-2
Journal Detail:
Title:  American journal of physiology. Endocrinology and metabolism     Volume:  -     ISSN:  1522-1555     ISO Abbreviation:  Am. J. Physiol. Endocrinol. Metab.     Publication Date:  2014 Dec 
Date Detail:
Created Date:  2014-12-3     Completed Date:  -     Revised Date:  2014-12-4    
Medline Journal Info:
Nlm Unique ID:  100901226     Medline TA:  Am J Physiol Endocrinol Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  ajpendo.00340.2014     Citation Subset:  -    
Copyright Information:
Copyright © 2014, American Journal of Physiology - Endocrinology and Metabolism.
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