| Physical Training Modulates Structural and Functional Features of Cell Nuclei in Type II Myofibers of Old Mice. | |
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MedLine Citation:
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PMID: 21978085 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Aging is associated with a progressive loss of muscle mass, strength, and function, a condition known as sarcopenia, which represents an important risk factor for physical disability in elderly. The mechanisms leading to sarcopenia are still largely unknown, and no specific therapy is presently available to counteract its onset or progress. Many studies have stressed the importance of physical exercise as an effective approach to prevent/limit the age-related muscle mass loss. This study investigated the effects of physical training on pre-mRNA pathways in quadriceps and gastrocnemius muscles of old mice by ultrastructural cytochemistry: Structural and in situ molecular features of myonuclei and satellite cell nuclei of type II fibers were compared in exercised versus sedentary old mice, using adult individuals as control. Our results demonstrated that in myonuclei of old mice physical exercise stimulates pre-mRNA transcription, splicing, and export to the cytoplasm, likely increasing muscle protein turnover. In satellite cells, the effect of physical exercise seems to be limited to the reactivation of some factors involved in the transcriptional and splicing apparatus without increasing RNA production, probably making these quiescent cells more responsive to activating stimuli. |
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Authors:
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Manuela Malatesta; Patrizia Fattoretti; Marzia Giagnacovo; Carlo Pellicciari; Carlo Zancanaro |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-6 |
Journal Detail:
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Title: Rejuvenation research Volume: - ISSN: 1557-8577 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101213381 Medline TA: Rejuvenation Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1 Department of Neurological, Neuropsychological, Morphological and Motor Sciences, Anatomy and Histology Section, University of Verona , Verona, Italy . |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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