Document Detail


Physical Training Exerts Neuroprotective Effects in the Regulation of Neurochemical Factors in an Animal Model Of Parkinson's Disease.
MedLine Citation:
PMID:  23041759     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The effect of physical training on the neurochemical and oxidative stress markers were evaluated in the striatum of rats with Parkinson's disease (PD). Untrained+sham-operated (USO), untrained+PD (UPD), trained+sham-operated (TSO), and trained+PD (TPD) were submitted to training on the treadmill. The PD was induced and seven days after the lesion, the animals underwent a rotational test and euthanasia by decapitation. The striatum was homogenized for Western Blot with anti-tyrosine hydroxylase(TH), anti-brain-derived neurotrophic factor (BDNF), anti-alpha-synuclein, anti-sarcoplasmic reticulum Ca(2+)-ATPase (SERCAII), anti-superoxide dismutase (SOD), anti-catalase (CAT), anti-glutathione peroxidase (GPX), and specific buffer for oxidative damage (TBARS and carbonyl content). The UPD and TPD groups showed a clear rotational asymmetry, apart from a significant reduction in the level of TH, BDNF, alpha-synuclein, SOD, CAT, and GPX as well as an increase in the TBARS and carbonyl content, as observed in the UPD group. The TH level was not significantly altered but the TPD group increased the levels of BNDF, SERCA II, SOD, and CAT and decreased the oxidative damage in lipids and protein. The effects of exercise on PD indicate the possibility that exercise, to a certain extent, modulates neurochemical status in the striatum of rats, possibly by improving the oxidative stress parameters.
Authors:
T Tuon; S S Valvassori; J L Borges; T Luciano; C B Trom; L A Silva; J L Quevedo; C T Souza; F S Lira; R A Pinho
Related Documents :
10343269 - Oxygenation strategy and neurologic damage after deep hypothermic circulatory arrest. i...
24188979 - The critical role of o2 provision in the dynamic adjustment of oxidative phosphorylation.
19652469 - Dna microarray analysis of transcriptional responses of mouse spinal cords to physical ...
23493529 - The effect of green tea extract on fat oxidation at rest and during exercise: evidence ...
23072319 - Effect of treadmill exercise and ferula gummosa on myocardial hsp72, vascular function,...
24648779 - Whole-body cryotherapy: empirical evidence and theoretical perspectives.
17632019 - A simplified method of determining synovial fluid chondroitin sulfate chain length.
17313289 - Effect of short-term equal-volume resistance training with different workout frequency ...
15998109 - Radical scavenging capacity of wine anthocyanins is strongly ph-dependent.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-3
Journal Detail:
Title:  Neuroscience     Volume:  -     ISSN:  1873-7544     ISO Abbreviation:  Neuroscience     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ltd.
Affiliation:
Laboratory of Exercise Biochemistry and Physiology, Postgraduate Program in Health Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense, Criciúma, Santa Catarina, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Valproic acid induces the glutamate transporter EAAT3 in human oligodendroglioma cells.
Next Document:  Aggressive experience increases dendritic spine density within the nucleus accumbens core in female ...