| Physical Exercise for Patients Undergoing Hematopoietic Stem Cell Transplantation: Systematic Review and Meta-Analyses of Randomized Controlled Trials. | |
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MedLine Citation:
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PMID: 23224217 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: The treatment-related burden for patients undergoing hematopoietic stem cell transplantation (HSCT) may be relieved by physical exercises. PURPOSE: To summarize and analyze the evidence provided by randomized controlled trials (RCTs) on physical exercise interventions among patients with cancer undergoing HSCT. DATA SOURCES: PubMed, CINAHL, EMBASE, the Cochrane Library, and PEDro were searched for relevant RCTs up to October 1, 2011. STUDY SELECTION: Two reviewers screened articles on inclusion criteria and indentified relevant RCTs. DATA EXTRACTION: Two authors assessed the selected articles for risk of bias (ROB). Data extraction was performed by one reviewer. Meta-analyses were undertaken to estimate the outcomes quality of life (QOL), psychological well-being, and distress and fatigue. DATA SYNTHESIS: Eleven studies were included with study populations consisting of recipients undergoing either an allogeneic or autologous HSCT (n=734). Four studies had low ROB. The exercise interventions were performed before, during, and/or after hospitalization for the HSCT. Different exercise programs on endurance, resistance, and/or ADL training, progressive relaxation, and stretching were employed. Meta- analyses showed that exercise during hospitalization lead to a higher QOL (WMD: 8.72 [95% CI 3.13, 14.31], P=0.002) and less fatigue (SMD 0.53 [0.16, 0.91], P=0.005) in allogeneic patients at the moment of discharge from the hospital. No marked effects were found for psychological well-being and distress. Individual study results suggested significant positive effects on QOL, fatigue, psychological well-being, and distress and physical functioning. LIMITATIONS: Prevalent shortcomings in the included studies were the heterogeneity between studies and the lack of blinding of participants, personnel, and outcome assessment. CONCLUSION: The results suggest that recipients of HSCT may benefit from physical exercise. |
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Authors:
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Inge E P M van Haren; Hans Timmerman; Carin M Potting; Nicole M A Blijlevens; J Bart Staal; Maria W G Nijhuis-van der Sanden |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-6 |
Journal Detail:
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Title: Physical therapy Volume: - ISSN: 1538-6724 ISO Abbreviation: Phys Ther Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0022623 Medline TA: Phys Ther Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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I.E.P.M. van Haren, PT, MSc, Scientific Institute for Quality of Healthcare (IQ Healthcare), Radboud University Nijmegen Medical Centre, 114 IQ Healthcare, Postbus 9101, 6500 HB, Nijmegen, the Netherlands. |
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