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Physical Exercise for Patients Undergoing Hematopoietic Stem Cell Transplantation: Systematic Review and Meta-Analyses of Randomized Controlled Trials.
MedLine Citation:
PMID:  23224217     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: The treatment-related burden for patients undergoing hematopoietic stem cell transplantation (HSCT) may be relieved by physical exercises. PURPOSE: To summarize and analyze the evidence provided by randomized controlled trials (RCTs) on physical exercise interventions among patients with cancer undergoing HSCT. DATA SOURCES: PubMed, CINAHL, EMBASE, the Cochrane Library, and PEDro were searched for relevant RCTs up to October 1, 2011. STUDY SELECTION: Two reviewers screened articles on inclusion criteria and indentified relevant RCTs. DATA EXTRACTION: Two authors assessed the selected articles for risk of bias (ROB). Data extraction was performed by one reviewer. Meta-analyses were undertaken to estimate the outcomes quality of life (QOL), psychological well-being, and distress and fatigue. DATA SYNTHESIS: Eleven studies were included with study populations consisting of recipients undergoing either an allogeneic or autologous HSCT (n=734). Four studies had low ROB. The exercise interventions were performed before, during, and/or after hospitalization for the HSCT. Different exercise programs on endurance, resistance, and/or ADL training, progressive relaxation, and stretching were employed. Meta- analyses showed that exercise during hospitalization lead to a higher QOL (WMD: 8.72 [95% CI 3.13, 14.31], P=0.002) and less fatigue (SMD 0.53 [0.16, 0.91], P=0.005) in allogeneic patients at the moment of discharge from the hospital. No marked effects were found for psychological well-being and distress. Individual study results suggested significant positive effects on QOL, fatigue, psychological well-being, and distress and physical functioning. LIMITATIONS: Prevalent shortcomings in the included studies were the heterogeneity between studies and the lack of blinding of participants, personnel, and outcome assessment. CONCLUSION: The results suggest that recipients of HSCT may benefit from physical exercise.
Authors:
Inge E P M van Haren; Hans Timmerman; Carin M Potting; Nicole M A Blijlevens; J Bart Staal; Maria W G Nijhuis-van der Sanden
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-6
Journal Detail:
Title:  Physical therapy     Volume:  -     ISSN:  1538-6724     ISO Abbreviation:  Phys Ther     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0022623     Medline TA:  Phys Ther     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
I.E.P.M. van Haren, PT, MSc, Scientific Institute for Quality of Healthcare (IQ Healthcare), Radboud University Nijmegen Medical Centre, 114 IQ Healthcare, Postbus 9101, 6500 HB, Nijmegen, the Netherlands.
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