Document Detail


Physical exercise improves the peripheral microcirculation of patients with chronic heart failure.
MedLine Citation:
PMID:  19770806     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Patients with chronic heart failure (CHF) present with microcirculation alterations, partially attributed to endothelial dysfunction. Exercise training has been shown to induce beneficial effects in CHF patients. The aim of our study was to assess the effect of physical exercise on the microcirculation of CHF patients by near-infrared spectroscopy (NIRS).
METHODS: Sixteen consecutive stable CHF patients (men, n = 10; mean age = 50 +/- 12 years) participated in a 3-month rehabilitation program (3 sessions per week). All patients performed symptom-limited, ramp-incremental cardiopulmonary exercise testing on a cycle ergometer before and after the completion of the program. Measurements included peak oxygen uptake (VO2peak), VO2 at anaerobic threshold (AT), and first-degree slope of VO2 during the first minute of recovery (VO2/t slope). Tissue oxygen saturation was continuously measured by NIRS at the thenar muscle during a 3-minute vascular occlusion with a pneumatic cuff (occlusion technique) before and after the rehabilitation program.
RESULTS: The oxygen reperfusion rate (%/min) following the release of vascular occlusion increased significantly after the rehabilitation program (450 +/- 105 to 532 +/- 151, P = .004) as did vascular reactivity (from 27 +/- 13%/min to 39 +/- 21%/min, P = .006). In addition, there was a significant increase in VO2peak and AT (from 14.3 +/- 4.7 mL . kg . min to 16.7 +/- 6.3 mL . kg . min and from 9.5 +/- 3.6 mL . kg . min to 11.3 +/- 4 mL . kg . min, P = .007 and P = .012, respectively) as well as in VO2/t slope (from 0.35 +/- 0.17 to 0.51 +/- 0.07 mL . kg . min, P = .005).
CONCLUSIONS: Peripheral microcirculation of CHF patients measured by NIRS improved after the rehabilitation program. NIRS is a noninvasive technique that could be used to evaluate the effect of rehabilitation on the peripheral microcirculation of CHF patients.
Authors:
Vasiliki Gerovasili; Stavros Drakos; Maria Kravari; Konstantinos Malliaras; Eleftherios Karatzanos; Stavros Dimopoulos; Athanasios Tasoulis; Maria Anastasiou-Nana; Charis Roussos; Serafim Nanas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiopulmonary rehabilitation and prevention     Volume:  29     ISSN:  1932-751X     ISO Abbreviation:  J Cardiopulm Rehabil Prev     Publication Date:    2009 Nov-Dec
Date Detail:
Created Date:  2009-11-26     Completed Date:  2011-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101291247     Medline TA:  J Cardiopulm Rehabil Prev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  385-91     Citation Subset:  IM    
Affiliation:
Cardiopulmonary Exercise Testing and Rehabilitation Laboratory, Pulmonary & Critical Care Medicine Department, Evgenidio Hospital, National and Kapodistrian University of Athens, Athens, Greece.
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MeSH Terms
Descriptor/Qualifier:
Chronic Disease
Endothelium, Vascular / physiopathology*
Ergometry
Exercise Test
Exercise Therapy*
Exercise Tolerance
Female
Health Status Indicators
Heart Failure / physiopathology,  therapy*
Humans
Male
Microcirculation*
Middle Aged
Muscle, Skeletal / blood supply*
Oxygen Consumption
Peripheral Arterial Disease / diagnosis*
Program Evaluation
Prospective Studies
Quality of Life
Questionnaires
Spectroscopy, Near-Infrared
Statistics, Nonparametric

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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