Document Detail


Physical exercise, fasting glucose, and renal hyperfiltration in the general population: the Renal Iohexol Clearance Survey in Tromsø 6 (RENIS-T6).
MedLine Citation:
PMID:  22917703     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVES: Abnormally elevated GFR, or hyperfiltration, is a proposed mechanism for kidney injury in diabetes, prediabetes, and obesity. This study investigated whether lack of physical exercise is associated with hyperfiltration and whether exercise modifies the positive association between fasting glucose and measured GFR.
DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The Renal Iohexol Clearance Survey in Tromsø 6 measured GFR as single-sample plasma iohexol clearance in 1506 members of the general population (age 50-62 years) without diabetes, cardiovascular disease, or kidney disease. Leisure-time physical exercise was assessed by a self-administered questionnaire. Hyperfiltration was defined as GFR above the 90th percentile after adjustment for sex, age, weight, height, and use of renin-angiotensin system inhibitors.
RESULTS: High-intensity exercise was associated with lower adjusted odds of hyperfiltration in men (odds ratio [OR], 0.47; 95% confidence interval [CI], 0.28-0.80) but not in women (OR, 1.02; 95% CI, 0.60-1.72). In both sexes, high-intensity exercise modified the association between fasting glucose and GFR. A fasting glucose level 1 mmol/L higher was associated with a GFR that was 7.3 (95% CI, 4.0-10.6) and 6.2 (95% CI, 3.4-9.0) ml/min per 1.73 m(2) higher in men and women who never exercised or exercised with low intensity. There was no association between fasting glucose and GFR in men and women who exercised with high intensity (interaction, P<0.001).
CONCLUSIONS: High-intensity exercise was associated with lower odds of hyperfiltration in men and modified the association between glucose and GFR of both sexes in a population without diabetes.
Authors:
Toralf Melsom; Ulla Dorte Mathisen; Britt-Ann Winther Eilertsen; Ole C Ingebretsen; Trond Jenssen; Inger Njølstad; Marit D Solbu; Ingrid Toft; Bjørn O Eriksen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-08-23
Journal Detail:
Title:  Clinical journal of the American Society of Nephrology : CJASN     Volume:  7     ISSN:  1555-905X     ISO Abbreviation:  Clin J Am Soc Nephrol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-08     Completed Date:  2013-06-21     Revised Date:  2013-11-14    
Medline Journal Info:
Nlm Unique ID:  101271570     Medline TA:  Clin J Am Soc Nephrol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1801-10     Citation Subset:  IM    
Affiliation:
Section of Nephrology, University Hospital of North Norway, Tromsø, Norway. melsom@unn.no
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MeSH Terms
Descriptor/Qualifier:
Blood Glucose / analysis*
Exercise*
Fasting / blood*
Female
Glomerular Filtration Rate*
Humans
Iohexol / pharmacokinetics*
Male
Metabolic Clearance Rate
Middle Aged
Chemical
Reg. No./Substance:
0/Blood Glucose; 66108-95-0/Iohexol
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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