| Physical exercise for cancer patients with advanced disease: a randomized controlled trial. | |
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MedLine Citation:
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PMID: 21948693 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Physical exercise can improve cancer patients' functioning and reduce their symptom levels. A randomized, controlled trial was launched to test the hypothesis that physical exercise reduces fatigue and improves physical performance in cancer patients with advanced and incurable disease. METHODS: Cancer patients (n = 231) with a life expectancy ≤2 years were randomized to a physical exercise group (PEG, n = 121) or a control usual care group (UCG, n = 110). The PEG exercised under supervision 60 minutes twice a week for 8 weeks. Assessments were performed before and after the intervention. The primary outcome was physical fatigue (PF) measured by the Fatigue Questionnaire. Physical performance was a secondary outcome measured by the Shuttle Walk Test (SWT) and hand grip strength (HGS) test. Analyses were performed after multiple imputations for missing data. The trial is registered with ClinicalTrials.gov (identifier, NCT00397774). FINDINGS: Thirty-six percent of the PEG were lost to follow-up compared with 23% of the UCG, primarily as a result of disease progression. Seventy-eight PEG and 85 UCG patients completed the intervention. Analyses showed no significant between-group effects in PF. However, clinically and statistically significant between-group effects were found for the SWT and HGS test. INTERPRETATION: Fatigue was not reduced but physical performance (SWT and HGS test) was significantly improved after 8 weeks of physical exercise. Physical exercise might therefore be a suitable approach for maintaining physical capacity in cancer patients with incurable and advanced disease. |
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Authors:
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Line M Oldervoll; Jon H Loge; Stian Lydersen; Hanne Paltiel; May B Asp; Unni V Nygaard; Elisabeth Oredalen; Tone L Frantzen; Ingvild Lesteberg; Lise Amundsen; Marianne J Hjermstad; Dagny F Haugen; Ørnulf Paulsen; Stein Kaasa |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2011-09-26 |
Journal Detail:
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Title: The oncologist Volume: 16 ISSN: 1549-490X ISO Abbreviation: Oncologist Publication Date: 2011 |
Date Detail:
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Created Date: 2011-11-30 Completed Date: 2012-06-13 Revised Date: 2013-02-19 |
Medline Journal Info:
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Nlm Unique ID: 9607837 Medline TA: Oncologist Country: United States |
Other Details:
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Languages: eng Pagination: 1649-57 Citation Subset: IM |
Affiliation:
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European Palliative Care Research Centre, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway. line.oldervoll@ntnu.no |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00397774 |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Exercise Exercise Therapy / methods* Fatigue / etiology, therapy Female Humans Lost to Follow-Up Male Middle Aged Neoplasms / complications, therapy* Prospective Studies Quality of Life Survival Analysis |
| Comments/Corrections | |
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