| Physical activity recommendations, exercise intensity, and histological severity of nonalcoholic fatty liver disease. | |
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MedLine Citation:
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PMID: 21206486 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Factors that determine disease severity in nonalcoholic fatty liver disease (NAFLD) are unclear, but exercise is a recommended treatment. We evaluated the association between physical activity intensity and histological severity of NAFLD. METHODS: We conducted a retrospective analysis of adults with biopsy-proven NAFLD enrolled in the NASH CRN (Nonalcoholic Steatohepatitis Clinical Research Network). Using self-reported time spent in physical activity, we classified participants as inactive or as meeting the US guidelines for either moderate or vigorous exercise. Histology was reviewed by a central pathology committee. Frequency and odds of steatohepatitis (NASH) and advanced fibrosis were compared between subjects who either met or did not meet exercise recommendations, and by the total amount of exercise per week. RESULTS: A total of 813 adults (males=302, females=511) with NAFLD were included, with a mean age of 48 years. Neither moderate-intensity exercise nor total exercise per week was associated with NASH or stage of fibrosis. Meeting vigorous recommendations was associated with a decreased adjusted odds of having NASH (odds ratio (OR): 0.65 (0.43-0.98)). Doubling the recommended time spent in vigorous exercise, as is suggested for achieving additional health benefits, was associated with a decreased adjusted odds of advanced fibrosis (OR: 0.53 (0.29-0.97)). CONCLUSIONS: These data support an association of vigorous but not moderate or total exercise with the severity of NAFLD. Optimal doses of exercise by duration and intensity for the prevention or treatment of NASH have not been established; however, intensity may be more important than duration or total volume. |
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Authors:
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Kristin D Kistler; Elizabeth M Brunt; Jeanne M Clark; Anna Mae Diehl; James F Sallis; Jeffrey B Schwimmer; |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural Date: 2011-01-04 |
Journal Detail:
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Title: The American journal of gastroenterology Volume: 106 ISSN: 1572-0241 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-07 Completed Date: 2011-04-28 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: United States |
Other Details:
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Languages: eng Pagination: 460-8; quiz 469 Citation Subset: IM |
Affiliation:
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Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego, California 92103, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Biological Markers / blood Biopsy Body Mass Index Cross-Sectional Studies Exercise* Fatty Liver / blood, epidemiology, pathology* Female Humans Liver / pathology* Liver Cirrhosis / pathology* Male Middle Aged Motor Activity* Odds Ratio Retrospective Studies Risk Factors Severity of Illness Index United States / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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M01RR000065/RR/NCRR NIH HHS; M01RR000750/RR/NCRR NIH HHS; M01RR000827/RR/NCRR NIH HHS; U01 DK061713-09/DK/NIDDK NIH HHS; U01 DK061718-09/DK/NIDDK NIH HHS; U01 DK061728-09/DK/NIDDK NIH HHS; U01 DK061730-09/DK/NIDDK NIH HHS; U01 DK061731-09/DK/NIDDK NIH HHS; U01 DK061732-09/DK/NIDDK NIH HHS; U01 DK061734-07/DK/NIDDK NIH HHS; U01 DK061737-08/DK/NIDDK NIH HHS; U01 DK061738-09/DK/NIDDK NIH HHS; U01DK061713/DK/NIDDK NIH HHS; U01DK061718/DK/NIDDK NIH HHS; U01DK061728/DK/NIDDK NIH HHS; U01DK061730/DK/NIDDK NIH HHS; U01DK061731/DK/NIDDK NIH HHS; U01DK061732/DK/NIDDK NIH HHS; U01DK061734/DK/NIDDK NIH HHS; U01DK061737/DK/NIDDK NIH HHS; U01DK061738/DK/NIDDK NIH HHS; UL1 RR024131-01/RR/NCRR NIH HHS; UL1 RR025014-01/RR/NCRR NIH HHS; UL1RR024989/RR/NCRR NIH HHS; UL1RR02501401/RR/NCRR NIH HHS; ULRR02413101//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
| Investigator | |
Investigator/Affiliation:
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Stephanie Abrams / ; Diana Arceo / ; Denise Espinosa / ; Leanel Angeli Fairly / ; Carol Hawkins / ; Yao-Chang Liu / ; Margaret Stager / ; Arthur McCullough / ; Srinivasan Dasarathy / ; Ruth Sargent / ; Melissa Coffey / ; Karen Murray / ; Melissa Young / ; Parvathi Mohan / ; Kavita Nair / ; Manal Abdelmalek / ; Anna Mae Diehl / ; Marcia Gottfried / ; Cynthia Guy / ; Paul Killenberg / ; Samantha Kwan / ; Yi-Ping Pan / ; Dawn Piercy / ; Melissa Smith / ; Prajakta Bhimalli / ; Naga Chalasani / ; Oscar W Cummings / ; Lydia Lee / ; Linda Ragozzino / ; Raj Vuppalanchi / ; Elizabeth Byam / ; Ann Klipsch / ; Jean Molleston / ; Girish Subbarao / ; Kimberly Pfeifer / ; Ann Scheimann / ; Michael Torbenson / ; Sarah Barlow / ; Jose Derdoy / ; Joyce Hoffmann / ; Debra King / ; Andrea Morris / ; Joan Siegner / ; Susan Stewart / ; Brent A Tetri / ; Judy Thompson / ; Cynthia Behling / ; Lisa Clark / ; Janis Durelle / ; Tarek Hassanein / ; Joel E Lavine / ; Susana Mendoza / ; Jeffrey B Schwimmer / ; Claude Sirlin / ; Tanya Stein / ; Zobeida Palomares / ; Bradley Aouizerat / ; Kiran Bambha / ; Nathan M Bass / ; Linda D Ferrell / ; Danuta Filipowski / ; Raphael Merriman / ; Mark Pabst / ; Monique Rosenthal / ; Philip Rosenthal / ; Tessa Steel / ; Matthew Yeh / ; Sherry Boyett / ; Melissa J Contos / ; Michael Fuchs / ; Amy Jones / ; Velimir A C Luketic / ; Bimalijit Sandhu / ; Arun J Sanyal / ; Carol Sargeant / ; Kimberly Selph / ; Melanie White / ; Kris V Kowdley / ; Jody Mooney / ; James Nelson / ; Sarah Ackermann / ; Cheryl Saunders / ; Vy Trinh / ; Chia Wang / ; Elizabeth M Brunt / ; David Kleiner / ; Gilman D Grave / ; Terry T K Huang / ; Edward Doo / ; James Everhart / ; Jay Hoofnagle / ; Patricia R Robuck / ; Leonard Seeff / ; Patricia Belt / ; Frederick L Brancati / ; Jeanne M Clark / ; Ryan Colvin / ; Michele Donithan / ; Mika Green / ; Rosemary Hollick / ; Milana Isaacson / ; Wana Kim / ; Alison Lydecker / ; Pamela Mann / ; Laura Miriel / ; Alice Sternberg / ; James Tonascia / ; Aynur Ünalp-Arida / ; Mark Van Natta / ; Laura Wilson / ; Katherine Yates / |
| Comments/Corrections | |
Comment In:
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Am J Gastroenterol. 2011 Mar;106(3):470-5
[PMID:
21378763
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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