Document Detail

Physical activity and ocular perfusion pressure: the EPIC-Norfolk eye study.
MedLine Citation:
PMID:  21911585     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To examine the relationship between physical activity and ocular perfusion pressure (OPP), a consistent risk factor for glaucoma.
METHODS: The relationship between previous physical activity and current OPP in 5650 participants aged 48 to 90 who attended the first (1993-1997) and third (2006-2010) health check as part of the European Prospective Investigation into Cancer (EPIC)-Norfolk study was examined. Usual combined physical activity at work and leisure was assessed using a validated instrument. Individuals were categorized as inactive, moderately inactive, moderately active, or active. Three IOP measurements were obtained (Ocular Response Analyzer [ORA]; Reichert, Inc., Depew, NY). Mean Goldmann correlated IOP (IOPg) from one eye was used in the analysis. Systolic and diastolic blood pressure (BP) were recorded as the mean of two measurements taken with a sphygmomanometer. Associations between physical activity and low (≤40 mm Hg) mean OPP (2/3 mean arterial pressure - IOP) and low (≤50 mm Hg) diastolic OPP (diastolic BP - IOP) were tested using logistic regression, adjusting for age, sex, body mass index, social class, IOP, and BP.
RESULTS: Active people had a lower risk of mean OPP ≤ 40 mm Hg and diastolic OPP ≤ 50 mm Hg after adjusting for age, sex, social class, and body mass index (odds ratio, 0.75; 95% confidence interval [CI], 0.60-0.93; P < 0.01) and (odds ratio, 0.73, 95% CI, 0.58-0.93; P = 0.01), respectively. The association between physical activity and perfusion pressure was independent of IOP, but largely mediated through diastolic BP.
CONCLUSIONS: Lower levels of physical activity were associated with lower OPP. Further research is needed to investigate the potential benefit of increased physical activity as a safe and simple method of modifying glaucoma risk.
Jennifer L Y Yip; David C Broadway; Robert Luben; David F Garway-Heath; Shabina Hayat; Nichola Dalzell; Pak Sang Lee; Amit Bhaniani; Nicholas J Wareham; Kay-Tee Khaw; Paul J Foster
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-10-17
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  52     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-18     Completed Date:  2012-01-05     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8186-92     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Blood Pressure / physiology*
Body Mass Index
European Continental Ancestry Group
Exercise / physiology*
Glaucoma, Open-Angle / epidemiology,  prevention & control
Great Britain / epidemiology
Intraocular Pressure / physiology*
Middle Aged
Risk Factors
Tonometry, Ocular
Grant Support
G0401527//Medical Research Council; G1000143//Medical Research Council; MC_U106179471//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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