| Physical activity and ocular perfusion pressure: the EPIC-Norfolk eye study. | |
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MedLine Citation:
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PMID: 21911585 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To examine the relationship between physical activity and ocular perfusion pressure (OPP), a consistent risk factor for glaucoma. METHODS: The relationship between previous physical activity and current OPP in 5650 participants aged 48 to 90 who attended the first (1993-1997) and third (2006-2010) health check as part of the European Prospective Investigation into Cancer (EPIC)-Norfolk study was examined. Usual combined physical activity at work and leisure was assessed using a validated instrument. Individuals were categorized as inactive, moderately inactive, moderately active, or active. Three IOP measurements were obtained (Ocular Response Analyzer [ORA]; Reichert, Inc., Depew, NY). Mean Goldmann correlated IOP (IOPg) from one eye was used in the analysis. Systolic and diastolic blood pressure (BP) were recorded as the mean of two measurements taken with a sphygmomanometer. Associations between physical activity and low (≤40 mm Hg) mean OPP (2/3 mean arterial pressure - IOP) and low (≤50 mm Hg) diastolic OPP (diastolic BP - IOP) were tested using logistic regression, adjusting for age, sex, body mass index, social class, IOP, and BP. RESULTS: Active people had a lower risk of mean OPP ≤ 40 mm Hg and diastolic OPP ≤ 50 mm Hg after adjusting for age, sex, social class, and body mass index (odds ratio, 0.75; 95% confidence interval [CI], 0.60-0.93; P < 0.01) and (odds ratio, 0.73, 95% CI, 0.58-0.93; P = 0.01), respectively. The association between physical activity and perfusion pressure was independent of IOP, but largely mediated through diastolic BP. CONCLUSIONS: Lower levels of physical activity were associated with lower OPP. Further research is needed to investigate the potential benefit of increased physical activity as a safe and simple method of modifying glaucoma risk. |
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Authors:
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Jennifer L Y Yip; David C Broadway; Robert Luben; David F Garway-Heath; Shabina Hayat; Nichola Dalzell; Pak Sang Lee; Amit Bhaniani; Nicholas J Wareham; Kay-Tee Khaw; Paul J Foster |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-10-17 |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: 52 ISSN: 1552-5783 ISO Abbreviation: Invest. Ophthalmol. Vis. Sci. Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-18 Completed Date: 2012-01-05 Revised Date: 2013-01-09 |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 8186-92 Citation Subset: IM |
Affiliation:
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Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. jlyy2@medschl.cam.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Blood Pressure / physiology* Body Mass Index European Continental Ancestry Group Exercise / physiology* Female Glaucoma, Open-Angle / epidemiology, prevention & control Great Britain / epidemiology Humans Intraocular Pressure / physiology* Male Middle Aged Questionnaires Risk Factors Sphygmomanometers Tonometry, Ocular |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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