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Physical Activity and Differential Methylation of Breast Cancer Genes Assayed from Saliva: A Preliminary Investigation.
MedLine Citation:
PMID:  23054940     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: Individuals who exercise are at lower risk for breast cancer and have better post-diagnosis outcomes. The biological mechanisms behind this association are unclear, but DNA methylation has been suggested. METHODS: We developed a composite measure of DNA methylation across 45 CpG sites on genes selected a priori. We examined the association of this measure to self-reported physical activity and objectively measured cardiovascular fitness in a sample of healthy nonsmoking adults (n = 64) in an exercise promotion intervention. RESULTS: Individuals who were more physically fit and who exercised more minutes per week had lower levels of DNA methylation. Those who increased their minutes of physical activity over 12 months experienced decreases in DNA methylation. CONCLUSIONS: DNA methylation may be a mechanism linking exercise and cancer incidence and could serve as a biomarker for behavioral intervention trials. Studies with larger samples, objectively measured exercise, and more cancer-related markers are needed.
Authors:
Angela D Bryan; Renee E Magnan; Ann E Caldwell Hooper; Nicole Harlaar; Kent E Hutchison
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-3
Journal Detail:
Title:  Annals of behavioral medicine : a publication of the Society of Behavioral Medicine     Volume:  -     ISSN:  1532-4796     ISO Abbreviation:  Ann Behav Med     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8510246     Medline TA:  Ann Behav Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Psychology and Neuroscience, University of Colorado Boulder, UCB 345, Boulder, CO, 80309-0345, USA, angela.bryan@colorado.edu.
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