| Physical activity, biomarkers, and disease outcomes in cancer survivors: a systematic review. | |
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MedLine Citation:
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PMID: 22570317 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Cancer survivors often seek information about how lifestyle factors, such as physical activity, may influence their prognosis. We systematically reviewed studies that examined relationships between physical activity and mortality (cancer-specific and all-cause) and/or cancer biomarkers. METHODS: We identified 45 articles published from January 1950 to August 2011 through MEDLINE database searches that were related to physical activity, cancer survival, and biomarkers potentially relevant to cancer survival. We used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement to guide this review. Study characteristics, mortality outcomes, and biomarker-relevant and subgroup results were abstracted for each article that met the inclusion criteria (ie, research articles that included participants with a cancer diagnosis, mortality outcomes, and an assessment of physical activity). RESULTS: There was consistent evidence from 27 observational studies that physical activity is associated with reduced all-cause, breast cancer-specific, and colon cancer-specific mortality. There is currently insufficient evidence regarding the association between physical activity and mortality for survivors of other cancers. Randomized controlled trials of exercise that included biomarker endpoints suggest that exercise may result in beneficial changes in the circulating level of insulin, insulin-related pathways, inflammation, and, possibly, immunity; however, the evidence is still preliminary. CONCLUSIONS: Future research directions identified include the need for more observational studies on additional types of cancer with larger sample sizes; the need to examine whether the association between physical activity and mortality varies by tumor, clinical, or risk factor characteristics; and the need for research on the biological mechanisms involved in the association between physical activity and survival after a cancer diagnosis. Future randomized controlled trials of exercise with biomarker and cancer-specific disease endpoints, such as recurrence, new primary cancers, and cancer-specific mortality in cancer survivors, are warranted. |
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Authors:
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Rachel Ballard-Barbash; Christine M Friedenreich; Kerry S Courneya; Sameer M Siddiqi; Anne McTiernan; Catherine M Alfano |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2012-05-08 |
Journal Detail:
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Title: Journal of the National Cancer Institute Volume: 104 ISSN: 1460-2105 ISO Abbreviation: J. Natl. Cancer Inst. Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-06-08 Completed Date: 2012-08-06 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 7503089 Medline TA: J Natl Cancer Inst Country: United States |
Other Details:
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Languages: eng Pagination: 815-40 Citation Subset: IM |
Affiliation:
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Applied Research Program, Department of Health and Human Services, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-7344, USA. barbashr@mail.nih.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Breast Neoplasms
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mortality Confounding Factors (Epidemiology) Exercise Humans Inflammation / prevention & control* Insulin / blood* Motor Activity* Neoplasms / immunology, mortality*, therapy Physical Exertion* Predictive Value of Tests Prognosis Randomized Controlled Trials as Topic Survivors* Treatment Outcome Tumor Markers, Biological / blood* |
| Chemical | |
Reg. No./Substance:
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0/Insulin; 0/Tumor Markers, Biological |
| Comments/Corrections | |
Comment In:
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J Natl Cancer Inst. 2012 Jun 6;104(11):797-9
[PMID:
22570316
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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