| Phylogeographic origin of Helicobacter pylori is a determinant of gastric cancer risk. | |
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MedLine Citation:
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PMID: 21357593 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND AIMS: Helicobacter pylori colonises the stomach in half of all humans, and is the principal cause of gastric cancer, the second leading cause of cancer death worldwide. While gastric cancer rates correlate with H pylori prevalence in some areas, there are regions where infection is nearly universal, but rates of gastric cancer are low. In the case of Colombia, there is a 25-fold increase in gastric cancer rate in the Andean mountain (high risk) region compared to the coastal (low risk) region, despite similarly high (∼90%) prevalence of H pylori in the two locations. Our aim was to investigate the ancestral origin of H pylori strains isolated from subjects in these high- and low-risk regions and to determine whether this is a predictive determinant of precancerous lesions. METHODS: Multi-locus sequence typing was used to investigate phylogeographic origins of infecting H pylori strains isolated from subjects in the Pacific coast and Andes Mountains in the state of Nariño, Colombia. We analysed 64 subjects infected with cagA+ vacA s1m1 strains. Gastric biopsy slides from each individual were scored for histological lesions and evaluated for DNA damage by immunohistochemistry. RESULTS: We show that strains from the high-risk region were all of European phylogeographic origin, whereas those from the low risk region were of either European (34%) or African origin (66%). European strain origin was strongly predictive of increased premalignant histological lesions and epithelial DNA damage, even in the low-risk region; African strain origin was associated with reduced severity of these parameters. CONCLUSION: The phylogeographic origin of H pylori strains provides an explanation for geographic differences in cancer risk deriving from this infection. |
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Authors:
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Thibaut de Sablet; M Blanca Piazuelo; Carrie L Shaffer; Barbara G Schneider; Mohammad Asim; Rupesh Chaturvedi; Luis E Bravo; Liviu A Sicinschi; Alberto G Delgado; Robertino M Mera; Dawn A Israel; Judith Romero-Gallo; Richard M Peek; Timothy L Cover; Pelayo Correa; Keith T Wilson |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Date: 2011-02-25 |
Journal Detail:
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Title: Gut Volume: 60 ISSN: 1468-3288 ISO Abbreviation: Gut Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-08-08 Completed Date: 2011-10-13 Revised Date: 2013-01-11 |
Medline Journal Info:
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Nlm Unique ID: 2985108R Medline TA: Gut Country: England |
Other Details:
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Languages: eng Pagination: 1189-95 Citation Subset: AIM; IM |
Affiliation:
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Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University School of Medicine, MRBIV, Room 1030C, 2215 Garland Avenue, Nashville, TN 37232, USA. keith.wilson@vanderbilt.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bacterial Typing Techniques Biopsy Cell Transformation, Neoplastic / genetics DNA Damage Gastric Mucosa / metabolism, microbiology, pathology Helicobacter Infections / complications, microbiology*, pathology Helicobacter pylori / classification, genetics*, pathogenicity Humans Male Middle Aged Phylogeny Precancerous Conditions / genetics, microbiology*, pathology Stomach Neoplasms / genetics, microbiology*, pathology |
| Grant Support | |
ID/Acronym/Agency:
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KL2 RR024977/RR/NCRR NIH HHS; KL2 TR000446/TR/NCATS NIH HHS; P01 CA028842/CA/NCI NIH HHS; P01 CA028842-24/CA/NCI NIH HHS; P01 CA116087-03/CA/NCI NIH HHS; P01CA028842/CA/NCI NIH HHS; P01CA116087/CA/NCI NIH HHS; P30 DK058404-10/DK/NIDDK NIH HHS; P30DK058404/DK/NIDDK NIH HHS; R01 AI039657-14/AI/NIAID NIH HHS; R01 AI068009-03/AI/NIAID NIH HHS; R01 AT004821-03/AT/NCCAM NIH HHS; R01 AT004821-04/AT/NCCAM NIH HHS; R01 CA077955-13/CA/NCI NIH HHS; R01 CA077955-15/CA/NCI NIH HHS; R01 DK053620/DK/NIDDK NIH HHS; R01 DK053620-10/DK/NIDDK NIH HHS; R01 DK058587/DK/NIDDK NIH HHS; R01 DK058587-09/DK/NIDDK NIH HHS; R01AI039657/AI/NIAID NIH HHS; R01AI068009/AI/NIAID NIH HHS; R01CA77955/CA/NCI NIH HHS; R01DK053620/DK/NIDDK NIH HHS; R01DK58587/DK/NIDDK NIH HHS; TL1 RR024978/RR/NCRR NIH HHS; TL1 TR000447/TR/NCATS NIH HHS; UL1 RR024975/RR/NCRR NIH HHS; UL1 RR024975-04/RR/NCRR NIH HHS; UL1 TR000445/TR/NCATS NIH HHS; UL1RR024975/RR/NCRR NIH HHS |
| Comments/Corrections | |
Comment In:
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Gut. 2012 Mar;61(3):469-70
[PMID:
21610271
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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