Document Detail


Phylogenetic analysis of developmental and postnatal mouse cell lineages.
MedLine Citation:
PMID:  20156285     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fate maps depict how cells relate together through past lineage relationships, and are useful tools for studying developmental and somatic processes. However, with existing technologies, it has not been possible to generate detailed fate maps of complex organisms such as the mouse. We and others have therefore proposed a novel approach, "phylogenetic fate mapping," where patterns of somatic mutation carried by the individual cells of an animal are used to retrospectively deduce lineage relationships through phylogenetic inference. Here, we have cataloged genomic polymorphisms at 324 mutation-prone polyguanine tracts for nearly 300 cells isolated from a single mouse, and have explored the cells' lineage relationships both phylogenetically and through a network-based approach. We present a model of mouse embryogenesis, where an early period of substantial cell mixing is followed by more coherent growth of clones later. We find that cells from certain tissues have greater numbers of close relatives in other specific tissues than expected from chance, suggesting that those populations arise from a similar pool of ancestral lineages. Finally, we have investigated the dynamics of cell turnover (the frequency of cell loss and replacement) in postnatal tissues. This work offers a longitudinal study of developmental lineages, from conception to adulthood, and provides insight into basic questions of mouse embryology as well as the somatic processes that occur after birth.
Authors:
Stephen J Salipante; Arnold Kas; Eva McMonagle; Marshall S Horwitz
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Evolution & development     Volume:  12     ISSN:  1525-142X     ISO Abbreviation:  Evol. Dev.     Publication Date:    2010 Jan-Feb
Date Detail:
Created Date:  2010-02-16     Completed Date:  2010-05-25     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  100883432     Medline TA:  Evol Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  84-94     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, Polyomavirus Transforming / genetics
Base Sequence
Bayes Theorem
Cells, Cultured
DNA Primers / genetics
Embryonic Development / genetics*
Gene Regulatory Networks
Genotype
Male
Mice
Mice, Transgenic
Mitosis / genetics
Models, Biological
Phylogeny*
Zygote / cytology,  metabolism
Grant Support
ID/Acronym/Agency:
DP1 OD003278/OD/NIH HHS; DP1 OD003278-03/OD/NIH HHS; DP1OD003278/OD/NIH HHS; F30AG030316/AG/NIA NIH HHS; R01 DK078340/DK/NIDDK NIH HHS; R01 DK078340-02/DK/NIDDK NIH HHS; R01DK078340/DK/NIDDK NIH HHS; T32 GM007454/GM/NIGMS NIH HHS; T32 GM007454-31/GM/NIGMS NIH HHS; T32GM007266/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, Polyomavirus Transforming; 0/DNA Primers
Comments/Corrections
Comment In:
Nature. 2010 Sep 16;467(7313):255   [PMID:  20844503 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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