| Phylogenetic analysis of Brazilian HIV type 1 subtype D strains: tracing the origin of this subtype in Brazil. | |
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MedLine Citation:
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PMID: 16478405 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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HIV-1 Subtype D occurs mainly in East and Central African countries, especially Uganda, where the prevalence of HIV-1 infection is among the highest in the world. We present the phylogenetic analysis of one nonautochthonous and four autochthonous (including a near full-length genome) Brazilian HIV-1 subtype D strains identified in Rio de Janeiro State, where subtypes B, F1, and BF1 recombinants predominate. Phylogenetic inferences using maximum likelihood were applied on a near-full length genome and on concatenated gag, protease, reverse transcriptase, integrase, C2V3/env, gp41, and nef segments. Sequences from an Angolan immigrant showed close genetic similarity with a strain described in Finland, from an HIV patient of African origin, whereas all four autochthonous Brazilian sequences clustered with South African strains, where subtype D occurs only in isolated cases. Our results suggest the successful introduction and circulation in Brazil of closely related HIV-1 subtype D strains, possibly of South African origin. |
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Authors:
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José Carlos Couto-Fernandez; Walter A Eyer-Silva; Monick L Guimarães; Saada L Chequer-Fernandez; Beatriz Grinsztejn; Eric Delaporte; Martine Peeters; Mariza G Morgado |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: AIDS research and human retroviruses Volume: 22 ISSN: 0889-2229 ISO Abbreviation: AIDS Res. Hum. Retroviruses Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-02-15 Completed Date: 2006-06-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8709376 Medline TA: AIDS Res Hum Retroviruses Country: United States |
Other Details:
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Languages: eng Pagination: 207-11 Citation Subset: IM; X |
Affiliation:
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Laboratório de AIDS & Imunologia Molecular, Departamento de Imunologia-ioc, Fundação Oswaldo Cruz, Av. Brasil 4365, Pavilhão Leônidas Deane, 413-415 Manguinhos, Rio de Janeiro-RJ, 21.045-900 Brazil. coutofer@ioc.fiocruz.br |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/DQ138968; DQ138969; DQ138970; DQ138971; DQ138972; DQ138973; DQ138974; DQ138975; DQ138976; DQ138977; DQ138978; DQ138979; DQ138980; DQ138981; DQ138982; DQ138983; DQ138984; DQ141202; DQ141203; DQ141204; DQ141205; DQ141206; DQ141207; DQ141208; DQ141209; DQ141210 |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brazil Genes, nef Genome, Viral HIV Envelope Protein gp41 / genetics HIV Protease / genetics HIV Reverse Transcriptase / genetics HIV-1 / classification*, genetics Integrases / genetics Likelihood Functions Molecular Sequence Data Phylogeny* |
| Chemical | |
Reg. No./Substance:
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0/HIV Envelope Protein gp41; EC 2.7.7.-/Integrases; EC 2.7.7.49/HIV Reverse Transcriptase; EC 3.4.23.-/HIV Protease |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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