Document Detail


Phylogenetic analysis of Brazilian HIV type 1 subtype D strains: tracing the origin of this subtype in Brazil.
MedLine Citation:
PMID:  16478405     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
HIV-1 Subtype D occurs mainly in East and Central African countries, especially Uganda, where the prevalence of HIV-1 infection is among the highest in the world. We present the phylogenetic analysis of one nonautochthonous and four autochthonous (including a near full-length genome) Brazilian HIV-1 subtype D strains identified in Rio de Janeiro State, where subtypes B, F1, and BF1 recombinants predominate. Phylogenetic inferences using maximum likelihood were applied on a near-full length genome and on concatenated gag, protease, reverse transcriptase, integrase, C2V3/env, gp41, and nef segments. Sequences from an Angolan immigrant showed close genetic similarity with a strain described in Finland, from an HIV patient of African origin, whereas all four autochthonous Brazilian sequences clustered with South African strains, where subtype D occurs only in isolated cases. Our results suggest the successful introduction and circulation in Brazil of closely related HIV-1 subtype D strains, possibly of South African origin.
Authors:
José Carlos Couto-Fernandez; Walter A Eyer-Silva; Monick L Guimarães; Saada L Chequer-Fernandez; Beatriz Grinsztejn; Eric Delaporte; Martine Peeters; Mariza G Morgado
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  AIDS research and human retroviruses     Volume:  22     ISSN:  0889-2229     ISO Abbreviation:  AIDS Res. Hum. Retroviruses     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-15     Completed Date:  2006-06-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8709376     Medline TA:  AIDS Res Hum Retroviruses     Country:  United States    
Other Details:
Languages:  eng     Pagination:  207-11     Citation Subset:  IM; X    
Affiliation:
Laboratório de AIDS & Imunologia Molecular, Departamento de Imunologia-ioc, Fundação Oswaldo Cruz, Av. Brasil 4365, Pavilhão Leônidas Deane, 413-415 Manguinhos, Rio de Janeiro-RJ, 21.045-900 Brazil. coutofer@ioc.fiocruz.br
Data Bank Information
Bank Name/Acc. No.:
GENBANK/DQ138968;  DQ138969;  DQ138970;  DQ138971;  DQ138972;  DQ138973;  DQ138974;  DQ138975;  DQ138976;  DQ138977;  DQ138978;  DQ138979;  DQ138980;  DQ138981;  DQ138982;  DQ138983;  DQ138984;  DQ141202;  DQ141203;  DQ141204;  DQ141205;  DQ141206;  DQ141207;  DQ141208;  DQ141209;  DQ141210
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MeSH Terms
Descriptor/Qualifier:
Brazil
Genes, nef
Genome, Viral
HIV Envelope Protein gp41 / genetics
HIV Protease / genetics
HIV Reverse Transcriptase / genetics
HIV-1 / classification*,  genetics
Integrases / genetics
Likelihood Functions
Molecular Sequence Data
Phylogeny*
Chemical
Reg. No./Substance:
0/HIV Envelope Protein gp41; EC 2.7.7.-/Integrases; EC 2.7.7.49/HIV Reverse Transcriptase; EC 3.4.23.-/HIV Protease

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