| Phylogenetic Analysis of Near Full-Length HIV-1 Genomic Sequences from 21 Korean Individuals. | |
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MedLine Citation:
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PMID: 23199052 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The Korean subclade of subtype B (KSB) is the most prevalent HIV-1 strain found in Korea. To date, only 2 near full-length HIV-1 sequences from Korean patients have been reported. Here, we analyzed a total of 24 near full-length genomes of HIV-1 strains that were isolated from 17 antiretroviral therapy (ART)-naïve patients and 4 ART-exposed patients. Provial DNA from peripheral blood mononuclear cells was PCR amplified and directly sequenced. Phylogenetic analyses were used to classify viruses from 19 patients as KSB, from 1 patient as subtype B, from 1 patient as subtype D, and 3 viruses from 1 patient as CRF02_AG. All KSB viruses demonstrated TAAAA instead of TATAA at the TATA box in the LTR. Of the 19 KSB patients, their sequence identities at nucleotide level ranged from 89.8 to 97.1% from the lowest env gene to the highest pol gene. Other than the CRF02_AG viruses, no recombination events were noted in any of the 19 KSB patients, which is consistent with our previous studies on the pol, vif, and nef genes. Except for one strain, all of the strains were classified as non-syncytium-inducing. This is the first report to describe near full-length KSB. |
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Authors:
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Young Keol Cho; Junh-En Kim; Brian Thomas Foley |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-2 |
Journal Detail:
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Title: AIDS research and human retroviruses Volume: - ISSN: 1931-8405 ISO Abbreviation: AIDS Res. Hum. Retroviruses Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8709376 Medline TA: AIDS Res Hum Retroviruses Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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University of Ulsan College of Medicine, Microbiology, 388-1 Poongnap-dong, Songpa-ku, Seoul, Korea, Republic of, 138-040, 82-2-3010-4283, 82-2-3010-4283; ykcho2@amc.seoul.kr. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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