| Phyllodes tumor of the breast. | |
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MedLine Citation:
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PMID: 17931796 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To better identify prognostic factors for local control and survival, as well as the role of different therapeutic options, for phyllodes tumors, a rare fibroepithelial neoplasm of the breast. METHODS AND MATERIALS: Data from 443 women treated between 1971 and 2003 were collected from the Rare Cancer Network. The median age was 40 years (range, 12-87 years). Tumors were benign in 284 cases (64%), borderline in 80 cases (18%), and malignant in 79 cases (18%). Surgery consisted of breast-conserving surgery (BCS) in 377 cases (85%) and total mastectomy (TM) in 66 cases (15%). Thirty-nine patients (9%) received adjuvant radiotherapy (RT). RESULTS: After a median follow-up of 106 months, local recurrence (LR) and distant metastases rates were 19% and 3.4%, respectively. In the malignant and borderline group (n = 159), RT significantly decreased LR (p = 0.02), and TM had better results than BCS (p = 0.0019). Multivariate analysis revealed benign histology, negative margins, and no residual disease (no RD) after initial treatment and RT delivery as independent favorable prognostic factors for local control; benign histology and low number of mitosis for disease-free survival; and pathologic tumor size < or = 3 cm and no tumor necrosis for overall survival. In the malignant and borderline subgroup multivariate analysis TM was the only favorable independent prognostic factor for disease-free survival. CONCLUSIONS: This study showed that phyllodes tumor patients with no RD after treatment have better local control. Benign tumors have a good prognosis after surgery alone. In borderline and malignant tumors, TM had better results than BCS. Thus, in these forms adjuvant RT should be considered according to histologic criteria. |
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Authors:
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Yazid Belkacémi; Guilhem Bousquet; Hugo Marsiglia; Isabelle Ray-Coquard; Nicolas Magné; Yann Malard; Magalie Lacroix; Cristina Gutierrez; Elzbieta Senkus; David Christie; Karen Drumea; Edouard Lagneau; Sidney P Kadish; Luciano Scandolaro; David Azria; Mahmut Ozsahin |
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Publication Detail:
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Type: Journal Article; Multicenter Study Date: 2007-10-10 |
Journal Detail:
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Title: International journal of radiation oncology, biology, physics Volume: 70 ISSN: 0360-3016 ISO Abbreviation: Int. J. Radiat. Oncol. Biol. Phys. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-01-21 Completed Date: 2008-03-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603616 Medline TA: Int J Radiat Oncol Biol Phys Country: United States |
Other Details:
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Languages: eng Pagination: 492-500 Citation Subset: IM |
Affiliation:
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Centre Oscar Lambret, Lille, France. y-belkacemi@o-lambret.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Analysis of Variance Breast Neoplasms / pathology, radiotherapy, surgery* Child Female Follow-Up Studies Humans Mastectomy Mastectomy, Segmental Middle Aged Neoplasm Recurrence, Local Phyllodes Tumor / pathology, radiotherapy, secondary, surgery* Prognosis Radiotherapy, Adjuvant Survival Rate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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