Document Detail

Physicochemical properties and applications of poly(lactic-co-glycolic acid) for use in bone regeneration.
MedLine Citation:
PMID:  23350707     Owner:  NLM     Status:  MEDLINE    
Poly(lactic-co-glycolic acid) (PLGA) is the most often used synthetic polymer within the field of bone regeneration owing to its biocompatibility and biodegradability. As a consequence, a large number of medical devices comprising PLGA have been approved for clinical use in humans by the American Food and Drug Administration. As compared with the homopolymers of lactic acid poly(lactic acid) and poly(glycolic acid), the co-polymer PLGA is much more versatile with regard to the control over degradation rate. As a material for bone regeneration, the use of PLGA has been extensively studied for application and is included as either scaffolds, coatings, fibers, or micro- and nanospheres to meet various clinical requirements.
Rosa P Félix Lanao; Anika M Jonker; Joop G C Wolke; John A Jansen; Jan C M van Hest; Sander C G Leeuwenburgh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-03-01
Journal Detail:
Title:  Tissue engineering. Part B, Reviews     Volume:  19     ISSN:  1937-3376     ISO Abbreviation:  Tissue Eng Part B Rev     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-06-21     Completed Date:  2014-01-17     Revised Date:  2014-08-04    
Medline Journal Info:
Nlm Unique ID:  101466660     Medline TA:  Tissue Eng Part B Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  380-90     Citation Subset:  IM    
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MeSH Terms
Absorbable Implants*
Bone Regeneration*
Bone Substitutes*
Lactic Acid*
Polyglycolic Acid*
Tissue Scaffolds*
Reg. No./Substance:
0/Bone Substitutes; 0/polylactic acid-polyglycolic acid copolymer; 26009-03-0/Polyglycolic Acid; 33X04XA5AT/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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