| Phthalocyanine photodynamic therapy: new strategy for closure of choroidal neovascularization. | |
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MedLine Citation:
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PMID: 7527887 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chloro-aluminum sulfonated phthalocyanine (CASPc) is a photo-chemically active dye employed in photodynamic therapy (PDT). CASPc is a potent generator of singlet oxygen when irradiated with 675 nm light and is also capable of fluorescence, allowing visualization of the dye in tissues. We devised an angiography system using CASPc fluorescence to determine its localization in experimental choroidal neovascularization in monkeys and then investigated the ability of CASPc to produce photochemical closure of neovascularization upon irradiation with 675nm laser light. Fluorescent imaging indicated that CASPc localized angiographically in areas of neovascularization for at least 24 hours. Irradiation with 675 nm laser light 5-30 minutes after CASPc injection produced complete closure of choroidal neovascularization with minimal damage to overlying retina. We conclude that CASPc localizes in neovascular choroidal vessels and that CASPc photodynamic therapy can produce closure of these choroidal vessels. |
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Authors:
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G H Kliman; C A Puliafito; D Stern; S Borirakchanyavat; W A Gregory |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Lasers in surgery and medicine Volume: 15 ISSN: 0196-8092 ISO Abbreviation: Lasers Surg Med Publication Date: 1994 |
Date Detail:
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Created Date: 1995-01-17 Completed Date: 1995-01-17 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8007168 Medline TA: Lasers Surg Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2-10 Citation Subset: IM |
Affiliation:
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Laser Research Laboratory, New England Eye Center, Boston, Massachusetts 02111. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aluminum Animals Choroid / blood supply*, pathology Disease Models, Animal Fluorescein Angiography Fundus Oculi Indoles / radiation effects, therapeutic use* Laser Therapy Macaca fascicularis Neovascularization, Pathologic / drug therapy*, pathology Organometallic Compounds / radiation effects, therapeutic use* Photochemotherapy* Radiation-Sensitizing Agents / radiation effects, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Indoles; 0/Organometallic Compounds; 0/Radiation-Sensitizing Agents; 104469-80-9/chloroaluminum tetrasulfophthalocyanine; 7429-90-5/Aluminum |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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