Document Detail

Phthalocyanine photodynamic therapy: new strategy for closure of choroidal neovascularization.
MedLine Citation:
PMID:  7527887     Owner:  NLM     Status:  MEDLINE    
Chloro-aluminum sulfonated phthalocyanine (CASPc) is a photo-chemically active dye employed in photodynamic therapy (PDT). CASPc is a potent generator of singlet oxygen when irradiated with 675 nm light and is also capable of fluorescence, allowing visualization of the dye in tissues. We devised an angiography system using CASPc fluorescence to determine its localization in experimental choroidal neovascularization in monkeys and then investigated the ability of CASPc to produce photochemical closure of neovascularization upon irradiation with 675nm laser light. Fluorescent imaging indicated that CASPc localized angiographically in areas of neovascularization for at least 24 hours. Irradiation with 675 nm laser light 5-30 minutes after CASPc injection produced complete closure of choroidal neovascularization with minimal damage to overlying retina. We conclude that CASPc localizes in neovascular choroidal vessels and that CASPc photodynamic therapy can produce closure of these choroidal vessels.
G H Kliman; C A Puliafito; D Stern; S Borirakchanyavat; W A Gregory
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Lasers in surgery and medicine     Volume:  15     ISSN:  0196-8092     ISO Abbreviation:  Lasers Surg Med     Publication Date:  1994  
Date Detail:
Created Date:  1995-01-17     Completed Date:  1995-01-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8007168     Medline TA:  Lasers Surg Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2-10     Citation Subset:  IM    
Laser Research Laboratory, New England Eye Center, Boston, Massachusetts 02111.
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MeSH Terms
Choroid / blood supply*,  pathology
Disease Models, Animal
Fluorescein Angiography
Fundus Oculi
Indoles / radiation effects,  therapeutic use*
Laser Therapy
Macaca fascicularis
Neovascularization, Pathologic / drug therapy*,  pathology
Organometallic Compounds / radiation effects,  therapeutic use*
Radiation-Sensitizing Agents / radiation effects,  therapeutic use*
Reg. No./Substance:
0/Indoles; 0/Organometallic Compounds; 0/Radiation-Sensitizing Agents; 104469-80-9/chloroaluminum tetrasulfophthalocyanine; 7429-90-5/Aluminum

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