Document Detail

Phthalates and their metabolites in breast milk - Results from the Bavarian Monitoring of Breast Milk (BAMBI).
MedLine Citation:
PMID:  21406311     Owner:  NLM     Status:  Publisher    
Phthalates have long been used as plasticizers to soften plastic products and, thus, are ubiquitous in modern life. As part of the Bavarian Monitoring of Breast Milk (BAMBI), we aimed to characterize the exposure of infants to phthalates in Germany. Overall, 15 phthalates, including di-2-ethylhexyl phthalate (DEHP), di-n-butyl phthalate (DnBP), di-isobutyl phthalate (DiBP), di-isononyl phthalate (DiNP), three primary metabolites of DEHP [mono-(2-ethylhexyl) phthalate (MEHP), mono-isobutyl phthalate (MiBP), and mono-n-butyl phthalate (MnBP)], and two secondary metabolites of DEHP were analyzed in 78 breast milk samples. We found median concentrations of 3.9ng/g for DEHP, 0.8ng/g for DnBP, and 1.2ng/g for DiBP, while other parent phthalates were found in only some or none of the samples at levels above the limit of quantitation. In infant formula (n=4) we observed mean values of 19.7ng/g (DEHP), 3.8ng/g (DnBP), and 3.6ng/g (DiBP). For MEHP, MiBP, and MnBP, the median values in breast milk were 2.3μg/l, 11.8μg/l, and 2.1μg/l, respectively. The secondary metabolites were not detected in any samples. Using median and 95th percentile values, we estimated an "average" and "high" daily intake for an exclusively breast-fed infant of 0.6μg/kg body weight (b.w.) and 2.1μg/kg b.w., respectively, for DEHP, 0.1μg/kg b.w. and 0.5μg/kg b.w. for DnBP, and 0.2μg/kg b.w. and 0.7μg/kg b.w. for DiBP. For DiNP, intake values were 3.2μg/kg b.w. and 6.4μg/kg b.w., respectively, if all values in milk were set half of the detection limit or the detection limit. The above-mentioned "average" and "high" intake values corresponded to only about 2% to 7%, respectively, of the recommended tolerable daily intake. Thus, it is not likely that an infant's exposure to phthalates from breast milk poses any significant health risk. Nevertheless, other sources of phthalates in this vulnerable phase have to be considered. Moreover, it should be noted that for infants nourished with formula, phthalate intake is of the same magnitude or slightly higher (DEHP) than for exclusively breast-fed infants.
H Fromme; L Gruber; E Seckin; U Raab; S Zimmermann; M Kiranoglu; M Schlummer; U Schwegler; S Smolic; W Völkel;
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-14
Journal Detail:
Title:  Environment international     Volume:  -     ISSN:  1873-6750     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7807270     Medline TA:  Environ Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2010. Published by Elsevier Ltd.
Bavarian Health and Food Safety Authority, Department of Chemical Safety and Toxicology, D-80538 Munich, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A gene delivery system based on the N-terminal domain of human toposiomerase I.
Next Document:  Characterization of myofibroblasts in chronic thromboembolic pulmonary hypertension.