Document Detail


Phrenic nerve diabetic neuropathy in rats: unmyelinated fibers morphometry.
MedLine Citation:
PMID:  19691536     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have demonstrated that phrenic nerves' large myelinated fibers in streptozotocin (STZ)-induced diabetic rats show axonal atrophy, which is reversed by insulin treatment. However, studies on structural abnormalities of the small myelinated and the unmyelinated fibers in the STZ-model of neuropathy are limited. Also, structural changes in the endoneural vasculature are not clearly described in this model and require detailed study. We have undertaken morphometric studies of the phrenic nerve in insulin-treated and untreated STZ-diabetic rats and non-diabetic control animals over a 12-week period. The presence of neuropathy was assessed by means of transmission electron microscopy, and morphometry of the unmyelinated fibers was performed. The most striking finding was the morphological evidence of small myelinated fiber neuropathy due to the STZ injection, which was not protected or reversed by conventional insulin treatment. This neuropathy was clearly associated with severe damage of the endoneural vessels present on both STZ groups, besides the insulin treatment. The STZ-diabetes model is widely used to investigate experimental diabetic neuropathies, but few studies have performed a detailed assessment of either unmyelinated fibers or capillary morphology in this animal model. The present study adds useful information for further investigations on the ultrastructural basis of nerve function in diabetes.
Authors:
Valéria Paula S Fazan; Omar A Rodrigues Filho; Caroline E R Jordão; Kenneth C Moore
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the peripheral nervous system : JPNS     Volume:  14     ISSN:  1529-8027     ISO Abbreviation:  J. Peripher. Nerv. Syst.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-08-20     Completed Date:  2009-10-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9704532     Medline TA:  J Peripher Nerv Syst     Country:  United States    
Other Details:
Languages:  eng     Pagination:  137-45     Citation Subset:  IM    
Affiliation:
Department of Surgery and Anatomy, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil. vpsfazan@yahoo.com.br
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Glucose / drug effects
Body Weight / drug effects
Cell Count
Cell Size / drug effects
Diabetes Mellitus, Experimental / drug therapy,  pathology*
Diabetic Neuropathies / pathology*
Hypoglycemic Agents / therapeutic use
Insulin / therapeutic use
Male
Nerve Fibers, Myelinated / pathology,  ultrastructure
Nerve Fibers, Unmyelinated / pathology*,  ultrastructure
Phrenic Nerve / pathology*,  ultrastructure
Rats
Rats, Wistar
Time Factors
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Hypoglycemic Agents; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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