| Phototransformations of advanced glycation end products in the human eye lens due to ultraviolet A light irradiation. | |
| | |
MedLine Citation:
|
PMID: 16037236 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Previous studies from this laboratory have shown that ultraviolet A (UVA) light can bleach the yellow advanced glycation end products (AGEs) of aged and cataractous human lenses. The AGEs OP-lysine and argpyrimidine are two UVA-absorbing posttranslational modifications that are abundant in the eye lens. The purpose of this study was to outline the changes in these two AGEs due to UVA irradiation. The changes of OP-lysine, OP-phenethylamine (a phenethylamine analogue of OP-lysine), and argpyrimidine due to irradiation with UVA light in the presence or absence of air and ascorbic acid were followed by different spectral methods. Aged human lenses were similarly irradiated in artificial aqueous humor. The amounts of OP-lysine in the irradiated lenses and in the corresponding dark controls were determined by HPLC. Both OP-lysine and argpyrimidine decreased 20% when irradiated with UVA light in the absence of ascorbic acid. Under the same conditions, OP-lysine was bleached 80% in the presence of ascorbic acid during irradiation experiments. In contrast, argpyrimidine UVA light bleaching was not affected by the presence of ascorbic acid. Interestingly the major product of OP-phenethylamine after UVA irradiation in the presence of ascorbic acid was phenethylamine, which indicates that the entire heterocycle of this AGE was cleaved and the initial amino group was restored. Some AGEs in the human eye lens can be transformed by UVA light. |
| | |
Authors:
|
O K Argirov; B Lin; B J Ortwerth |
Related Documents
:
|
163386 - Ascorbic acid for the common cold. a prophylactic and therapeutic trial. 6949636 - Identification of ascorbic acid as the heat-stable factor from brain which inactivates ... 15667596 - Effect of sodium azulene sulfonate on capsaicin-induced pharyngitis in rats. 7872786 - Ascorbic acid transport and distribution in human b lymphocytes. 7086186 - Structure-function relationship in the evolution of elastin. 163386 - Ascorbic acid for the common cold. a prophylactic and therapeutic trial. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Annals of the New York Academy of Sciences Volume: 1043 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2005 Jun |
Date Detail:
|
Created Date: 2005-07-22 Completed Date: 2005-10-27 Revised Date: 2013-06-09 |
Medline Journal Info:
|
Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
|
Languages: eng Pagination: 166-73 Citation Subset: IM |
Affiliation:
|
Mason Eye Institute-East, University of Missouri at Columbia, 404 Portland Street, Columbia, MO 65201, USA. argirovo@health.missouri.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Glycosylation End Products, Advanced
/
radiation effects* Humans Lens, Crystalline / physiology*, radiation effects Lysine / analogs & derivatives, radiation effects Protein Processing, Post-Translational Pyridinium Compounds / radiation effects Ultraviolet Rays* |
| Grant Support | |
ID/Acronym/Agency:
|
EY 07070/EY/NEI NIH HHS; EY02035/EY/NEI NIH HHS; R01 EY002035-28/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/2-amino-6-(3-oxidopyridinium-1-yl)hexanoic acid; 0/Glycosylation End Products, Advanced; 0/Pyridinium Compounds; 56-87-1/Lysine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dicarbonyl stress and apoptosis of vascular cells: prevention by alphaB-crystallin.
Next Document: The maillard reaction for sunlight protection.