Document Detail

Phototransformation of sensitisers: 3. Implications for clinical dosimetry.
MedLine Citation:
PMID:  24710987     Owner:  NLM     Status:  In-Data-Review    
Spectroscopic studies of aqueous solutions of haematoporphyrin-type sensitisers reveal that photobleaching during eposure to light is followed by the formation of stable red-absorbing photoproducts. Experiments in model systems (sensitisers bound to human serum albumin or in a suspension of resealed erythrocyte 'ghosts') and in tumour tissue show that similar photomodification takes place in all investigated environments. Loss of total absorption and emission intensities is accompanied by an increase of absorption in the red spectral region (630-650 nm) which is used for the treatment of tumours because of the deeper penetration of light into tissues. This should be taken into account when the duration of illumination is chosen to reach an appropriate photodynamic dose using Hp-type sensitisers in the photodynamic treatment of tumours.
R Rotomskis; S Bagdonas; G Streckyte; R Wendenburg; W Dietel; J Didziapetriene; A Ibelhauptaite; L Staciokiene
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lasers in medical science     Volume:  13     ISSN:  0268-8921     ISO Abbreviation:  Lasers Med Sci     Publication Date:  1998 Dec 
Date Detail:
Created Date:  2014-04-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8611515     Medline TA:  Lasers Med Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  271-8     Citation Subset:  -    
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