Document Detail


Phototransformation of sensitisers: 3. Implications for clinical dosimetry.
MedLine Citation:
PMID:  24710987     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Spectroscopic studies of aqueous solutions of haematoporphyrin-type sensitisers reveal that photobleaching during eposure to light is followed by the formation of stable red-absorbing photoproducts. Experiments in model systems (sensitisers bound to human serum albumin or in a suspension of resealed erythrocyte 'ghosts') and in tumour tissue show that similar photomodification takes place in all investigated environments. Loss of total absorption and emission intensities is accompanied by an increase of absorption in the red spectral region (630-650 nm) which is used for the treatment of tumours because of the deeper penetration of light into tissues. This should be taken into account when the duration of illumination is chosen to reach an appropriate photodynamic dose using Hp-type sensitisers in the photodynamic treatment of tumours.
Authors:
R Rotomskis; S Bagdonas; G Streckyte; R Wendenburg; W Dietel; J Didziapetriene; A Ibelhauptaite; L Staciokiene
Related Documents :
22534917 - Single-shot color fringe projection for three-dimensional shape measurement of objects ...
22528857 - Doped quantum dots for white-light-emitting diodes without reabsorption of multiphase p...
10229697 - A kinematic comparison of forward and backward swimming in the eel anguilla anguilla
23188267 - Axially symmetric polarization converter made of patterned liquid crystal quarter wave ...
18190897 - Using spatial frequency scales for processing face features and face configuration: an ...
23811737 - Two-phase strategy of neural control for planar reaching movements: ii-relation to spat...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lasers in medical science     Volume:  13     ISSN:  0268-8921     ISO Abbreviation:  Lasers Med Sci     Publication Date:  1998 Dec 
Date Detail:
Created Date:  2014-04-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8611515     Medline TA:  Lasers Med Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  271-8     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Histological Examination of Bronchial Mucosa after Photodynamic Therapy Showing no Selectivity of Ef...
Next Document:  A preliminary study of the in vivo behaviour of an emulsion formulation of indocyanine green.