Document Detail


Phototoxicity of tetracyclines as related to singlet oxygen production and uptake by polymorphonuclear leukocytes.
MedLine Citation:
PMID:  3741478     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The photo-induced singlet oxygen production of six tetracyclines was measured as tryptophan degradation. Demethylchlortetracycline was the most efficient singlet oxygen producer followed by doxycycline. The least efficient producer was minocycline. Doxycycline, however, was the most potent inducer of photodamage to polymorphonuclear leukocytes (PMNLs) followed by demethylchlortetracycline. Accordingly, the singlet oxygen production during irradiation did not correlate with the induction of photodamage to the PMNLs. However, the uptake of doxycycline by the cells was 3 times higher than that of demethylchlortetracycline, and the tetracycline-induced photodamage to the PMNLs correlated with the product of singlet oxygen production during irradiation and the drug uptake by the cells.
Authors:
J Glette; S Sandberg
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical pharmacology     Volume:  35     ISSN:  0006-2952     ISO Abbreviation:  Biochem. Pharmacol.     Publication Date:  1986 Sep 
Date Detail:
Created Date:  1986-09-25     Completed Date:  1986-09-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0101032     Medline TA:  Biochem Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2883-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Free Radicals
Humans
Neutrophils / drug effects,  metabolism*
Oxygen / metabolism*
Photosensitivity Disorders / chemically induced*
Tetracyclines / toxicity*
Chemical
Reg. No./Substance:
0/Free Radicals; 0/Tetracyclines; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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