| Photothermal optical coherence tomography in ex vivo human breast tissues using gold nanoshells. | |
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MedLine Citation:
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PMID: 20195324 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We demonstrate photothermal optical coherence tomography (OCT) imaging in highly scattering human breast tissue ex vivo. A 120 kHz axial scan rate, swept-source phase-sensitive OCT system at 1300 nm was used to detect phase changes induced by 830 nm photothermal excitation of gold nanoshells. Localized phase modulation was observed 300-600 microm deep in scattering tissue using an excitation power of only 22 mW at modulation frequencies up to 20 kHz. This technique enables integrated structural and molecular-targeted imaging for cancer markers using nanoshells. |
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Authors:
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Chao Zhou; Tsung-Han Tsai; Desmond C Adler; Hsiang-Chieh Lee; David W Cohen; Amy Mondelblatt; Yihong Wang; James L Connolly; James G Fujimoto |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Optics letters Volume: 35 ISSN: 1539-4794 ISO Abbreviation: Opt Lett Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-02 Completed Date: 2010-06-02 Revised Date: 2012-05-16 |
Medline Journal Info:
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Nlm Unique ID: 7708433 Medline TA: Opt Lett Country: United States |
Other Details:
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Languages: eng Pagination: 700-2 Citation Subset: IM |
Affiliation:
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Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Breast
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cytology* Contrast Media / chemistry* Female Gold / chemistry, diagnostic use* Hot Temperature Humans Molecular Probe Techniques* Nanoparticles / chemistry, diagnostic use* Reproducibility of Results Sensitivity and Specificity Tomography, Optical Coherence / methods* |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA075289/CA/NCI NIH HHS; R01 CA075289-14/CA/NCI NIH HHS; R01 CA075289-15/CA/NCI NIH HHS; R01-CA75289-13/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 7440-57-5/Gold |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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