| Phototherapy promotes healing of chronic diabetic leg ulcers that failed to respond to other therapies. | |
| | |
MedLine Citation:
|
PMID: 19588536 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: We tested the hypothesis that combined 660 and 890 nm LED phototherapy will promote healing of diabetic ulcers that failed to respond to other forms of treatment. RESEARCH DESIGN AND METHODS: A double-blind randomized placebo controlled design was used to study 23 diabetic leg ulcers in two groups of 14 patients. Group one ulcers were cleaned, dressed with 1% silver sulfadiazine cream and treated with "placebo" phototherapy (<1.0 J cm(-2)) twice per week, using a Dynatron Solaris 705(R) device. Group two ulcers were treated similarly but received 3 J cm(-2) dose. RESULTS: At each of 15, 30, 45, 60, 75, and 90 days of healing, mean ulcer granulation and healing rates were significantly higher for group two than the "placebo" group (P < 0.02). While "placebo" treated ulcers worsened during the initial 30 days, group two ulcers healed rapidly; achieving 56% more granulation and 79.2% faster healing by day 30, and maintaining similarly higher rates of granulation and healing over the "placebo" group all through. By day 90, 58.3% of group two ulcers had healed fully and 75% had achieved 90-100% healing. In contrast, only one "placebo" treated ulcer healed fully by day 90; no other ulcer attained > or =90% healing. CONCLUSION: Combined 660 and 890 nm light promotes rapid granulation and healing of diabetic ulcers that failed to respond to other forms of treatment. |
| | |
Authors:
|
Debora G Minatel; Marco Andrey C Frade; Suzelei C França; Chukuka S Enwemeka |
Related Documents
:
|
6654626 - Cytoprotective effect of vitamin a and its clinical importance in the treatment of pati... 20980766 - Can you combine herbal therapy with physical agents in the treatment of venous leg ulce... 12762426 - Topical phenytoin versus eusol in the treatment of non-malignant chronic leg ulcers. 15210456 - Ultrasound-guided injection of polidocanol microfoam in the management of venous leg ul... 22952106 - Significance of ultrasound in the diagnosis and treatment of achilles tendon rupture. 18303156 - Intravitreal bevacizumab (avastin) therapy versus photodynamic therapy plus intravitrea... |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Lasers in surgery and medicine Volume: 41 ISSN: 1096-9101 ISO Abbreviation: Lasers Surg Med Publication Date: 2009 Aug |
Date Detail:
|
Created Date: 2009-07-15 Completed Date: 2009-11-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8007168 Medline TA: Lasers Surg Med Country: United States |
Other Details:
|
Languages: eng Pagination: 433-41 Citation Subset: IM |
Copyright Information:
|
Copyright 2009 Wiley-Liss, Inc. |
Affiliation:
|
Department of Biotechnology, University of Ribeirão Preto, Ribeirão Preto, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Cohort Studies Diabetes Mellitus, Type 2 / complications*, pathology, physiopathology Double-Blind Method Female Granulation Tissue / pathology, radiation effects Humans Laser Therapy, Low-Level / instrumentation* Lasers, Semiconductor / therapeutic use* Leg Ulcer / etiology, pathology, radiotherapy* Male Middle Aged Treatment Outcome Wound Healing / radiation effects* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Port wine stain progression: a potential consequence of delayed and inadequate treatment?
Next Document: Posttraumatic stress disorder symptoms in cancer: psychometric analysis of the Spanish Posttraumatic...