Document Detail

Phototherapy for neonatal hyperbilirubinemia--a potential environmental health hazard to newborn infants: a review.
MedLine Citation:
PMID:  399916     Owner:  NLM     Status:  MEDLINE    
Phototherapy has been shown to be an effective therapy for severe neonatal jaundice. However, because of its seemingly innocuous effect on normal babies, this therapeutic modality has been widely used to prevent jaundice in circumstances where it may be neither necessary nor beneficial. The present report summarizes results which indicate that phototherapy is endowed with DNA-modifying properties and has therefore the potential for inducing genetic and carcinogenic effects. These disconcerting findings concerning the long-term hazardous consequences of an accepted therapeutic procedure require that the unique physiologic and pharmacologic characteristics of the newborn populations be recognized when assessing the risks and benefits of phototherapy.
W T Speck; H S Rosenkranz
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Environmental mutagenesis     Volume:  1     ISSN:  0192-2521     ISO Abbreviation:  Environ Mutagen     Publication Date:  1979  
Date Detail:
Created Date:  1981-03-17     Completed Date:  1981-03-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7909737     Medline TA:  Environ Mutagen     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  321-36     Citation Subset:  IM    
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MeSH Terms
Bilirubin / radiation effects
Cell Line
DNA / radiation effects*
Infant, Newborn
Jaundice, Neonatal / therapy*
Mutagenicity Tests
Phototherapy / adverse effects*
Riboflavin / radiation effects
Salmonella typhimurium / genetics,  radiation effects
Grant Support
1KO-4-CA-00443/CA/NCI NIH HHS; 5RO1-CA-23692/CA/NCI NIH HHS; N01-CP-33395/CP/NCI NIH HHS
Reg. No./Substance:
635-65-4/Bilirubin; 83-88-5/Riboflavin; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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