Document Detail


Phototherapy increases hemoglobin degradation and bilirubin production in preterm infants.
MedLine Citation:
PMID:  10685237     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To compare hemoglobin degradation and bilirubin production before and during phototherapy in preterm infants. BACKGROUND: Hemoglobin is catabolized into globin and heme, which is degraded by microsomal heme oxygenase into equimolar carbon monoxide and biliverdin. Biliverdin is then reduced into bilirubin. CO is excreted exclusively by the lungs; therefore, end-tidal carbon monoxide, corrected for inhaled CO (ETCOc), reflects hemoglobin degradation and total bilirubin production. METHOD: A prospective study design was used, including a study group of 24 preterm infants requiring phototherapy. Infants with hemolytic diseases, sepsis, recent blood transfusion, and infants on mechanical ventilation were excluded. ETCOc was measured in preterm infants before and during phototherapy. Hemoglobin degradation and bilirubin production were calculated by measuring ETCOc. RESULTS: The (mean +/- SD) birth weight of 24 preterm neonates was 1975 +/- 613 gm, gestational age was 32.7 +/- 2.3 weeks, hematocrit was 47.5 +/- 6.2 volume%, and peak bilirubin was 13.1 +/- 3.2 mg/dl. First ETCOc measurements were done at 59.6 +/- 22.2 hours of age immediately before starting phototherapy. The second ETCOc measurements were taken at 13.7 +/- 7.9 hours after starting phototherapy. The second measurement of 2.6 +/- 0.6 ppm (mean +/- SD) was significantly higher than the first ETCOc of 2.1 +/- 0.6 ppm (p < 0.05). CONCLUSION: Phototherapy increases hemoglobin degradation and bilirubin production in preterm infants.
Authors:
M M Aouthmany
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  19     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:  1999 Jun 
Date Detail:
Created Date:  2000-03-13     Completed Date:  2000-03-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  271-4     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, St. Vincent Mercy Medical Center, Medical College of Ohio, Toledo, USA.
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MeSH Terms
Descriptor/Qualifier:
Bilirubin / biosynthesis*
Birth Weight
Female
Hematocrit
Hemoglobins / metabolism*
Humans
Infant, Newborn
Infant, Premature / physiology*
Male
Phototherapy*
Prospective Studies
Chemical
Reg. No./Substance:
0/Hemoglobins; 635-65-4/Bilirubin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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