Document Detail

Phototherapy: from ancient Egypt to the new millennium.
MedLine Citation:
PMID:  11803408     Owner:  NLM     Status:  MEDLINE    
Phototherapy with ultraviolet light was widely and successfully used in the past for treatment of a variety of diseases. Phototherapy with visible light alone has no benefit except in the therapy and prophylaxis of unconjugated hyperbilirubinemia. For this purpose, radiation in the region of approximately 480 to 500 nm is most effective and radiation above approximately 550 nm is useless. The principle effect of the treatment is not photodegradation of bilirubin, but conversion of the pigment to structural isomers that are more polar and more readily excreted than the normal, more toxic "dark" form of the pigment. This, coupled with some photooxidation of bilirubin, diminishes the overall pool of bilirubin in the body and lowers plasma levels. In the future, phototherapy may be supplanted by pharmacologic treatment, but in the near future, the most likely advance will be the introduction of novel forms of light production and delivery.
A F McDonagh
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Publication Detail:
Type:  Historical Article; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  21 Suppl 1     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2002-01-22     Completed Date:  2002-02-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S7-S12     Citation Subset:  IM    
Division of Gastroenterology and the Liver Center, University of California-San Francisco, San Francisco, CA 94143-0538, USA.
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MeSH Terms
Bilirubin / chemistry,  metabolism
History, 17th Century
History, 18th Century
History, 19th Century
History, 20th Century
History, Ancient
Infant, Newborn
Jaundice, Neonatal / metabolism,  therapy*
Phototherapy* / history,  trends
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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