| Photoswitchable nanoparticles for triggered tissue penetration and drug delivery. | |
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MedLine Citation:
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PMID: 22385538 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a novel nanoparticulate drug delivery system that undergoes reversible volume change from 150 to 40 nm upon phototriggering with UV light. The volume change of these monodisperse nanoparticles comprising spiropyran, which undergoes reversible photoisomerization, and PEGylated lipid enables repetitive dosing from a single administration and enhances tissue penetration. The photoswitching allows particles to fluoresce and release drugs inside cells when illuminated with UV light. The mechanism of the light-induced size switching and triggered-release is studied. These particles provide spatiotemporal control of drug release and enhanced tissue penetration, useful properties in many disease states including cancer. |
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Authors:
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Rong Tong; Houman D Hemmati; Robert Langer; Daniel S Kohane |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-03-16 |
Journal Detail:
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Title: Journal of the American Chemical Society Volume: 134 ISSN: 1520-5126 ISO Abbreviation: J. Am. Chem. Soc. Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-05-30 Completed Date: 2012-09-28 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 7503056 Medline TA: J Am Chem Soc Country: United States |
Other Details:
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Languages: eng Pagination: 8848-55 Citation Subset: IM |
Affiliation:
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Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Line, Tumor Collagen / metabolism Cornea / metabolism, radiation effects Diffusion Drug Carriers / chemistry*, metabolism* Humans Light* Models, Molecular Molecular Conformation Nanoparticles / chemistry* Particle Size Permeability / radiation effects Surface Properties |
| Grant Support | |
ID/Acronym/Agency:
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R21DC009986/DC/NIDCD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Drug Carriers; 9007-34-5/Collagen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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