| Photostabilization of Ascorbic Acid with Citric Acid, Tartaric Acid and Boric Acid in Cream Formulations. | |
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MedLine Citation:
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PMID: 22296174 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The present study involves the evaluation of the effect of certain stabilizers, i.e. citric acid (CT), tartaric acid (TA) and boric acid (BA) on the degradation of ascorbic acid (AH(2) ) in oil-in-water cream formulations exposed to the UV light and stored in the dark. The apparent first-order rate constants (0.34-0.95×10(-3) min(-1) in light, 0.38-1.24×10(-2) day(-1) in dark) for the degradation reactions in the presence of the stabilizers have been determined. These rate constants have been used to derive the second-order rate constants (0.26-1.45×10(-2) M(-1) min(-1) in light, 3.75-8.50×10(-3) M(-1) day(-1) ) for the interaction of AH(2) and the individual stabilizers. These stabilizers are effective in causing the inhibition of the rate of degradation of AH(2) both in the light and in the dark. The inhibitory effect of the stabilizers is in the order of CT > TA > BA. The rate of degradation of AH(2) in the presence of these stabilizers in light is about 120 times higher than that in the dark. This could be explained on the basis of the deactivation of AH(2) excited triplet state by CT and TA and by complex formation with BA. AH(2) leads to the formation of dehydroascorbic acid (A) by chemical and photooxidation in cream formulations. © 2012 The Authors ICS © 2012 Society of Cosmetic Scientists and the Société Française de Cosmétologie. |
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Authors:
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Iqbal Ahmad; Muhammad Ali Sheraz; Sofia Ahmed; Zufi Shad; Faiyaz H M Vaid |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-2 |
Journal Detail:
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Title: International journal of cosmetic science Volume: - ISSN: 1468-2494 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8007161 Medline TA: Int J Cosmet Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Authors ICS © 2012 Society of Cosmetic Scientists and the Société Française de Cosmétologie. |
Affiliation:
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Institute of Pharmaceutical Sciences, Baqai Medical University, Toll Plaza, Super Highway, Gadap Road, Karachi-74600, Pakistan Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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