|Photostability of commercial sunscreens upon sun exposure and irradiation by ultraviolet lamps.|
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|PMID: 17324264 Owner: NLM Status: MEDLINE|
|BACKGROUND: Sunscreens are being widely used to reduce exposure to harmful ultraviolet (UV) radiation. The fact that some sunscreens are photounstable has been known for many years. Since the UV-absorbing ingredients of sunscreens may be photounstable, especially in the long wavelength region, it is of great interest to determine their degradation during exposure to UV radiation. Our aim was to investigate the photostability of seven commercial sunscreen products after natural UV exposure (UVnat) and artificial UV exposure (UVart). METHODS: Seven commercial sunscreens were studied with absorption spectroscopy. Sunscreen product, 0.5 mg/cm2, was placed between plates of silica. The area under the curve (AUC) in the spectrum was calculated for UVA (320-400 nm), UVA1 (340-400 nm), UVA2 (320-340 nm) and UVB (290-320 nm) before (AUCbefore) and after (AUCafter) UVart (980 kJ/m2 UVA and 12 kJ/m2 of UVB) and before and after UVnat. If theAUC Index (AUCI), defined as AUCI = AUCafter/AUCbefore, was > 0.80, the sunscreen was considered photostable. RESULTS: Three sunscreens were unstable after 90 min of UVnat; in the UVA range the AUCI was between 0.41 and 0.76. In the UVB range one of these sunscreens was unstable with an AUCI of 0.75 after 90 min. Three sunscreens were photostable after 120 min of UVnat; in the UVA range the AUCI was between 0.85 and 0.99 and in the UVB range between 0.92 and 1.0. One sunscreen showed in the UVA range an AUCI of 0.87 after UVnat but an AUCI of 0.72 after UVart. Five of the sunscreens were stable in the UVB region. CONCLUSION: The present study shows that several sunscreens are photounstable in the UVA range after UVnat and UVart. There is a need for a standardized method to measure photostability, and the photostability should be marked on the sunscreen product.|
|Helena Gonzalez; Nils Tarras-Wahlberg; Birgitta Strömdahl; Asta Juzeniene; Johan Moan; Olle Larkö; Arne Rosén; Ann-Marie Wennberg|
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|Type: Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-02-26|
|Title: BMC dermatology Volume: 7 ISSN: 1471-5945 ISO Abbreviation: BMC Dermatol. Publication Date: 2007|
|Created Date: 2007-03-26 Completed Date: 2007-05-01 Revised Date: 2009-11-18|
Medline Journal Info:
|Nlm Unique ID: 100968541 Medline TA: BMC Dermatol Country: England|
|Languages: eng Pagination: 1 Citation Subset: IM|
|Department of Dermatology, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden. firstname.lastname@example.org|
|APA/MLA Format Download EndNote Download BibTex|
Area Under Curve
Sunscreening Agents / chemistry*
Journal ID (nlm-ta): BMC Dermatol
Publisher: BioMed Central, London
Copyright ? 2007 Gonzalez et al; licensee BioMed Central Ltd.
open-access: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received Day: 1 Month: 9 Year: 2006
Accepted Day: 26 Month: 2 Year: 2007
collection publication date: Year: 2007
Electronic publication date: Day: 26 Month: 2 Year: 2007
Volume: 7First Page: 1 Last Page: 1
Publisher Id: 1471-5945-7-1
PubMed Id: 17324264
|Photostability of commercial sunscreens upon sun exposure and irradiation by ultraviolet lamps|
|Helena Gonzalez1||Email: email@example.com|
|Nils Tarras-Wahlberg2||Email: firstname.lastname@example.org|
|Birgitta Str?mdahl2||Email: email@example.com|
|Asta Juzeniene3||Email: firstname.lastname@example.org|
|Johan Moan3||Email: email@example.com|
|Olle Lark?1||Email: firstname.lastname@example.org|
|Arne Ros?n2||Email: email@example.com|
|Ann-Marie Wennberg1||Email: firstname.lastname@example.org|
1Department of Dermatology, Sahlgrenska University Hospital, SE-413 45 G?teborg, Sweden
2Department of Physics, G?teborg University, SE-412 96 G?teborg, Sweden
3Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, N-0310, Norway
Sunscreens give good protection against sunburn, actinic keratosis and squamous cell carcinoma. The results for preventing cutaneous malignant melanoma (CMM) and basal cell carcinoma are less conclusive [1-3]. One explanation for this can be that UVA radiation (320?400 nm) plays a role for induction of CMM  and that it is mainly in the UVA range the photodegradation of the sunscreen occurs. In the present work, commercially available sunscreens, containing organic chemical and/or inorganic chemical filters, have been exposed to natural UV (UVnat) as well as to artificial UV (UVart) in order to study their photostability.
Previous studies have shown that some sunscreens lose part of their protection when exposed to UV radiation [5-10]. Several sunscreen producers claim that their products give good protection against both UVA and UVB radiation; however, the photostability of the product is rarely declared. This is also important for the consumer to know when choosing a sunscreen. Since it has been known for several years that some products may be photounstable, one would have expected a large improvement in the photostability of sunscreen products. Up to now, there is no standard method for determining photostability of a sunscreen [6,11,12]. Neither is there an international standard method for measuring UVA protection, and several different systems are currently in use [13-16].
The aim of this study was to investigate the photostability of commercial sunscreen products after UVnat and after UVart.
Seven commercial sunscreens were included, all available on the Swedish market. Three sunscreens contained only organic chemical filters, three sunscreens had a combination of inorganic and organic chemical filters, and one sunscreen contained solely inorganic chemical filters. In Table 1 the photoactive compounds of the sunscreens and the Sun Protection Factor (SPF) of the product are shown.
The sunscreen was weighed and placed between two plates of polished fused silica (quartz) with diameter 25 mm and thickness 5 mm. The amount applied was 0.5 mg/cm2. The absorbance was too high for proper measurements when the recommended amount of 2 mg/cm2 was applied, causing distortion in the absorption spectrum. For this reason a thinner layer was applied. A previous study has shown that the result were independent whether an application thickness of 1 or 2 mg/cm2 was used .
For UVA radiation, a UVASUN 2000 (MUTZHAS, Germany) was used. The output is mainly between 340 and 400 nm.
For UV radiation (including UVB), an Essh? Corona Mini (Sweden), equipped with two fluorescent tubes, Philips TL 12 (20 W), was used. This is a broadband radiation source from 280 to 380 nm with a major peak at 313 nm. There are strong mercury peaks at 313 nm and 365 nm.
The irradiance at the exposure plane was measured with an International Light IL 1350 Radiometer/Photometer using a probe named SED 240 for UVA and a probe named SED 015 for UVB radiation. The fluence rate of the UVA lamp was 820 W/m2 when measured from a distance of 25 cm. Twenty minutes' exposure gave a dose of 980 kJ/m2. This corresponds to the UVA dose that reaches the earth's surface during one sunny summer day in Gothenburg . We also measured the spectral distribution of the UVB lamp. By combining the spectral distribution with the action spectrum of the probe, the fluence rate of the UVB radiation was 9.8 W/m2. Twenty minutes of exposure gave a dose of 12 kJ/m2 UV radiation (including UVB). This corresponds to 45 Standard Erythema Doses (SED) when further weighted by the CIE action spectrum . This is a much higher dose than normal for one summer day in Gothenburg  or what has been reported from Denmark . In spite of that fact, the majority of sunscreens showed good stability in the UVB range. In Table 2 the UV doses reported from the Swedish Metrological and Hydrological Institute (SMHI) are listed.
For UVnat, samples were placed horizontally outdoors when the weather was sunny. This was done in early July in Gothenburg (latitude: 57? 42' N). The total exposure time was 120 min (Table 2) with measurements of the absorption spectra before exposure and after 30 min, 90 min and 120 min of UVnat. SMHI measures the global irradiance in many places in Sweden and gives the CIE erythema weighted UV radiation as well (Table 2).
To eliminate the possibility that the degradation of the photoactive compounds could be caused by a temperature increase, control samples of sunscreen between silica plates were placed on a heating plate for 20 minutes. The temperature was kept at 50?C ? 2?C, which was the same as that measured during exposure to the UVA lamp. This is about 15?C higher than the temperature of the skin. Spectra were recorded prior to and after heating. The temperature did not influence the degradation since the absorption spectra did not change after heating.
In all studies the spectra were recorded by a Cary 4 spectrophotometer (Varian, USA). It is a two-beam spectrophotometer without integrating sphere, which measures the transmission by scanning over the wavelength range of interest. Without integrating sphere the measured absorbance includes also some scattered radiation. Therefore, the spectra of samples with inorganic filters, which scatter light, may show a too high absorbance.
The AUC for UVA, UVA1 (340?400 nm), UVA2 (320?340 nm) and UVB was calculated for each spectrum before (AUCbefore) and after (AUCafter) UVart (980 kJ/m2 UVA and 12 kJ/m2 of UV radiation (UVB included) and before and after UVnat. If the AUCI (AUCI = AUCafter/AUCbefore) was >0.80, the sunscreen was considered photostable.
The AUC was calculated with the following equation:
where A is absorption and ? is wavelength. It was measured in steps of 1 nm.
For UVA ?max = 400 nm and ?min = 320 nm. The same calculation was done for each UV range respectively, before and after UVart and before and after UVnat.
Maier et al. used the difference between the spectral transmission before and after a defined UV exposure, ?T. A product was labeled photounstable if the mean photoinstability was higher than 5% (1 mg/cm2 product was used) . In our study we chose the AUCI instead. Since we used 0.5 mg/cm2 we considered the product photostable if the AUCI was higher than 0.8.
The photostability of the sunscreens tested varies considerably. The photounstable sunscreens start to degrade rather rapidly when exposed to the sun. After 30 min of UVnat, Sunscreens 1 and 3 are unstable (AUCI <0.80). Sunscreens containing inorganic chemical filters are more photostable in our study than sunscreens with organic chemical filters with the exception of Sunscreens 3 and 5
Sunscreens 5, 6 and 7 are photostable after UVnat; in the UVA range the AUCI was between 0.85 and 0.99 after 120 min and between 0.92 and 1.0 in the UVB range. Sunscreen 4 shows in the UVA range an AUCI of 0.87 after UVnat but 0.72 after UVart.
Sunscreens 1, 2 and 3 are unstable. They show after 90 min UVnat an AUCI between 0.41 and 0.76 in the UVA range and between 0.30 and 0.69 in the UVA1 range.
Sunscreens 2, 4, 5, 6 and 7 are stable in the UVB region whereas Sunscreens 1 and 3 are not. During exposure, absorption ranges of Sunscreens 1, 2 and 3 are shifted towards shorter wavelengths (Fig. 1a?c).
In Table 3 the AUCI is presented.
This is true for all three samples, after both UVnat and UVart. Sunscreen 4 is more unstable after UVart than to UVnat (Fig. 2).
The spectra were normalized by dividing the maximum value of the spectrum before irradiation by itself, so that the peak value of the spectrum before irradiation was set to 1.
The temperature was higher, during exposure to the UVart than during exposure to UVnat, but the temperature did not influence the absorption. Sunscreens 5, 6 and 7 were stable both after UVart and after UVnat. Sunscreens 6 and 7 were very little influenced by UV exposure (Fig. 3a?c). In agreement with findings from other studies, sunscreens with the UV filter combination ethylhexyl methoxycinnamate (EHMC) and butyl methoxydibenzoylmethane (BMDBM) were unstable [6,9,21,22].
In most cases UVnat compared to the UVart gave qualitatively similar results. However, UVnat, with a lower fluence rate than UVart, gave similar yields of degradation. In addition, the fluence rate of the UVAart was higher than that of the UVAnat, which could be expected to degrade the sunscreens faster. But this is not the case, except for Sunscreen 4. Since the dose of UVAart was higher than UVAnat, Sunscreen 4 probably provides sufficient protection for the consumer.
Commercial sunscreens generally have low viscosity in order to be easy to apply. The temperature increase of the samples during UV exposure, especially after UVart, may lower the viscosity further. This may result in reductions of the optical path lengths of the samples. However, this was not the case in our study since samples kept on a heating plate for 20 min at 50?C showed a similar spectrum before and after heating.
Four of the seven sunscreens contain TiO2. If the particles are too small they may lose their scattering effect and, consequently, not give as good protection as larger particles. This may be the case for Sunscreen 5 (Fig. 3a). Several other studies show that inorganic chemical filters are not always photostable [6,9-11]. Our study indicates the opposite, but seven sunscreens are a quite small amount of material, so this finding should be interpreted with caution.
When mixed with petrolatum, some sunscreens undergo degradation during exposure to UV radiation, especially in the UVA range . This is also the case for one of the most frequently used UV filters BMDBM. This compound is included in six of the seven sunscreens studied here (Table 1). Our results confirm the findings from other studies that sunscreens containing the combination of EHMC and BMDBM are photounstable, regardless of what other UV filters they contain [6,9].
Some manufacturers of sunscreens claim that commercially available sunscreens are photostable because the photoactive species are in a vehicle that stabilizes them. This claim does not seem to be correct in several cases. There are several studies about how improvement of photostability may be obtained, e.g. with nanoparticle encapsulation of EHMC , liposphere preparation of BMDBM  or a combination with diethylhexyl syringylidene malonate and BMDBM . These findings are very interesting and will hopefully lead to an improvement in photostability in commercial available products.
When sunscreens without metallic oxide particles are compared, Sunscreen 1 seems to be more rapidly degraded than BMDBM dissolved in petrolatum. Not only does the UVA protection decline after exposure, but also the UVB protection. EHMC is one of the two UVB-absorbing filters present in Sunscreen 2, and the only one in Sunscreen 1. EHMC dissolved in petrolatum is rather photounstable . The vehicles of Sunscreens 1 and 2 are nearly identical. The UVA-absorbing compound benzophenone-3 (BZ-3) is added in Sunscreen 2. The presence of this compound may stabilize BMDBM, in agreement with earlier findings . Another stabilizer that may work is anisotrizine (CAS no 187393-00-6)is ; however, that compound was not included in any of the products in this study. Sunscreen 2 also has a higher SPF. However, a degradation manifesting itself in the UVA1 region should be noted.
Sunscreen 5 is photostable but does not contain any metallic oxide particles. This may be due to a vehicle that successfully prevents degradation and/or due to microstructures of the emulsion itself (Fig. 3a). It is interesting to compare this spectrum with that of Sunscreen 3 (Fig. 1c) which, according to the list of contents, includes TiO2 particles but does not show the scattering slope. The size of the particles may be too small (15 nm, according to the producer) to influence the absorption spectrum in the visible range. Small particles of TiO2 are expected to give maximal scattering in the UVB or UVC region. Larger particles can cause significant scattering also in the UVA and visible region. It follows that the small nanoparticles cannot give good protection in the UVA region in this case.
The peak between 350 and 375 nm in the absorption spectra of Sunscreens 3, 4 and 5 (Figs. 1c, 2, 3a) can be attributed to BMDBM. In view of this it should be noted that the UV exposure makes the products react quite differently. In Sunscreen 3 the BMDBM peak almost vanishes totally after 30 min of UVnat, while the peaks in the other two sunscreens are more stable. We suggested above why there could be degradation in the UVA range in Sunscreen 3 despite the presence of TiO2 particles. The reported stabilizing effect of 4-Methylbenzylidene camphor (MBC)  does not manifest itself in the case of Sunscreen 3.
The photostable Sunscreen 6 contains, in addition to BMDBM and TiO2, a third UVA absorber, terephthalylidene dicamphor sulfonic acid (TLDCSA), which can stabilize BMDBM. It has also been shown that TiO2 may stabilize ketoprofen and may be used in protecting photounstable species .
Many commercial sunscreens give, according to the manufacturers, good UVA and UVB protection. However, the photostability of the sunscreen in the UVA range is not always adequate. Most sunscreens offer good protection against UVB while the UVA photostability of some products decreases substantially during UV exposure. The potential toxicity of the photoproducts also needs to be investigated further.
For the consumer it is very difficult to know what product to choose, since the photostability varies between different brands and the photostability is not marked on the bottle. To know which photoactive compound the sunscreen contains is not good enough. The stability also depends on factors like preservatives, oxygen radical scavengers, and base formulation. It is not reasonable that the ordinary consumer should have knowledge of this. If the product claims to give broadband protection, this protection should remain also after sun exposure. The fact that sunscreens are photounstable has been known for many years. Our study clearly shows that there are still many photounstable products on the market. When buying a sunscreen, the consumer should automatically receive a photostable product.
The present study shows that several commercially available sunscreens are not photo stable. Degradation is clearly manifested in the absorption region in the UVA range after solar irradiation. In general, sunscreens with TiO2 particles seem to be more photostable, with Sunscreens 3 and 5 as exceptions. Special focus should be on the commonly used UVA absorber BMDBM. In three out of six sunscreens in our study this molecule was degraded during UV exposure. Stabilizers of BMDBM may work, but not under all conditions. There is a need for a standardized method to measure photostability and the photostability should be marked on the sunscreen product.
The author(s) declare that they have no competing interests.
HG and NT-W have made contributions to conception of design and interpretation of the data. They carried out the experimental set-up during the absorption studies and wrote the main part of the manuscript.
BS carried out some of the absorption studies and drafted the manuscript.
AR have made substantial contributions to conception of design, interpretation of the data and drafting and revising the manuscript. AR also participated in the coordination of the study.
AJ, JM, OL and A-MW have made substantial contribution to concept of design and drafting and revising the manuscript critically.
All authors read and approved the final manuscript.
The pre-publication history for this paper can be accessed here:
We gratefully acknowledge financial support from the Swedish Research Council for Engineering Science (TFR, contract no. 98?797) and the Welander Foundation. We also thank Dr Jerker M?rtensson, at Chalmers University of Technology for fruitful discussion, and Tomas Landelius and Weine Josefsson at SMHI.
|Green A,Williams G,Neale R,Hart V,Leslie D,Parsons P,Marks GC,Gaffney P,Battistutta D,Frost C,Lang C,Russell A. Daily sunscreen application and betacarotene supplementation in prevention of basal-cell and squamous-cell carcinomas of the skin: a randomised controlled trialLancet 1999;354:723–729. [pmid: 10475183] [doi: 10.1016/S0140-6736(98)12168-2]|
|Bastuji-Garin S,Diepgen TL. Cutaneous malignant melanoma, sun exposure, and sunscreen use: epidemiological evidenceBr J Dermatol 2002;146 Suppl 61:24–30. [pmid: 11966729] [doi: 10.1046/j.1365-2133.146.s61.9.x]|
|Huncharek M,Kupelnick B. Use of topical sunscreens and the risk of malignant melanoma: a meta-analysis of 9067 patients from 11 case-control studiesAm J Public Health 2002;92:1173–1177. [pmid: 12084704]|
|Moan J,Dahlback A,Setlow RB. Epidemiological support for an hypothesis for melanoma induction indicating a role for UVA radiationPhotochem Photobiol 1999;70:243–247. [pmid: 10461463] [doi: 10.1562/0031-8655(1999)070<0243:ESFAHF>2.3.CO;2]|
|Tarras-Wahlberg N,Stenhagen G,Larko O,Rosen A,Wennberg AM,Wennerstrom O. Changes in ultraviolet absorption of sunscreens after ultraviolet irradiationJ Invest Dermatol 1999;113:547–553. [pmid: 10504439] [doi: 10.1046/j.1523-1747.1999.00721.x]|
|Maier H,Schauberger G,Brunnhofer K,Honigsmann H. Change of ultraviolet absorbance of sunscreens by exposure to solar-simulated radiationJ Invest Dermatol 2001;117:256–262. [pmid: 11511302] [doi: 10.1046/j.0022-202x.2001.01425.x]|
|Haywood R,Wardman P,Sanders R,Linge C. Sunscreens inadequately protect against ultraviolet-A-induced free radicals in skin: implications for skin aging and melanoma?J Invest Dermatol 2003;121:862–868. [pmid: 14632206] [doi: 10.1046/j.1523-1747.2003.12498.x]|
|Marrot L,Belaidi JP,Lejeune F,Meunier JR,Asselineau D,Bernerd F. Photostability of sunscreen products influences the efficiency of protection with regard to UV-induced genotoxic or photoageing-related endpointsBr J Dermatol 2004;151:1234–1244. [pmid: 15606520] [doi: 10.1111/j.1365-2133.2004.06173.x]|
|Maier H,Schauberger G,Martincigh BS,Brunnhofer K,Honigsmann H. Ultraviolet protective performance of photoprotective lipsticks: change of spectral transmittance because of ultraviolet exposurePhotodermatol Photoimmunol Photomed 2005;21:84–92. [pmid: 15752126] [doi: 10.1111/j.1600-0781.2005.00143.x]|
|Serpone N,Salinaro A,Emeline AV,Horikoshi S,Hidaka H,Zhao J. An in vitro systematic spectroscopic examination of the photostabilities of a random set of commercial sunscreen lotions and their chemical UVB/UVA active agentsPhotochem Photobiol Sci 2002;1:970–981. [pmid: 12661594] [doi: 10.1039/b206338g]|
|Diffey BL,Stokes RP,Forestier S,Mazilier C,Rougier A. Suncare product photostability: a key parameter for a more realistic in vitro efficacy evaluationEur J Dermatol 1997:226–228.|
|Moyal D,Refregier JL,Chardon A. In vivo measurement of the photostability of sunscreen products using diffuse reflectance spectroscopyPhotodermatol Photoimmunol Photomed 2002;18:14–22. [pmid: 11982917] [doi: 10.1034/j.1600-0781.2002.180103.x]|
|Diffey BL,Tanner PR,Matts PJ,Nash JF. In vitro assessment of the broad-spectrum ultraviolet protection of sunscreen productsJ Am Acad Dermatol 2000;43:1024–1035. [pmid: 11100018] [doi: 10.1067/mjd.2000.109291]|
|Lim HW,Naylor M,Honigsmann H,Gilchrest BA,Cooper K,Morison W,Deleo VA,Scherschun L. American Academy of Dermatology Consensus Conference on UVA protection of sunscreens: summary and recommendations. Washington, DC, Feb 4, 2000J Am Acad Dermatol 2001;44:505–508. [pmid: 11209123] [doi: 10.1067/mjd.2001.112913]|
|Nash JF,Tanner PR,Matts PJ. Ultraviolet A radiation: testing and labeling for sunscreen productsDermatol Clin 2006;24:63–74. [pmid: 16311168] [doi: 10.1016/j.det.2005.08.005]|
|Moyal D,Wichrowski K,Tricaud C. In vivo persistent pigment darkening method: a demonstration of the reproducibility of the UVA protection factors results at several testing laboratoriesPhotodermatol Photoimmunol Photomed 2006;22:124–128. [pmid: 16719864] [doi: 10.1111/j.1600-0781.2006.00223.x]|
|Stokes R,Diffey BL. In vitro assessment of sunscreen photostability: the effect of radiation source, sunscreen application thickness and substrateInt J Cosmetic Sci 1999;21:341–351. [doi: 10.1046/j.1467-2494.1999.203163.x]|
|Josefsson W. Solar ultraviolet radiation in SwedenSMHI Reports meteorology and climatology. 1986|
|CIEErythema reference action spectrum and standard erythema dose, S007/E: ; Vienna, Austria.. 1998|
|Thieden E,Philipsen PA,Heydenreich J,Wulf HC. UV radiation exposure related to age, sex, occupation, and sun behavior based on time-stamped personal dosimeter readingsArch Dermatol 2004;140:197–203. [pmid: 14967793] [doi: 10.1001/archderm.140.2.197]|
|Bonda C,Marinelli P. The photochemistry of sunscreen photostability: 3-4 Nov; Paris. 1999Step Publishing Ltd; :46–51.|
|Sayre RM,Dowdy JC,Gerwig AJ,Shields WJ,Lloyd RV. Unexpected photolysis of the sunscreen octinoxate in the presence of the sunscreen avobenzonePhotochem Photobiol 2005;81:452–456. [pmid: 15560736] [doi: 10.1562/2004-02-12-RA-083.1]|
|Perugini P,Simeoni S,Scalia S,Genta I,Modena T,Conti B,Pavanetto F. Effect of nanoparticle encapsulation on the photostability of the sunscreen agent, 2-ethylhexyl-p-methoxycinnamateInt J Pharm 2002;246:37–45. [pmid: 12270607] [doi: 10.1016/S0378-5173(02)00356-3]|
|Iannuccelli V,Sala N,Tursilli R,Coppi G,Scalia S. Influence of liposphere preparation on butyl-methoxydibenzoylmethane photostabilityEur J Pharm Biopharm 2006;63:140–145. [pmid: 16531026] [doi: 10.1016/j.ejpb.2006.01.007]|
|Chaudhuri RK,Lascu Z,Puccetti G,Deshpande AA,Paknikar SK. Design of a photostabilizer having built-in antioxidant functionality and its utility in obtaining broad-spectrum sunscreen formulationsPhotochem Photobiol 2006;82:823–828. [pmid: 16492073] [doi: 10.1562/2005-07-15-RA-612]|
|W?nsch T,Westenfelder H. New aspects in sunscreens: 17-18 Nov; Paris. 1998Step Publishing Ltd; :56–60.|
|Chatelain E,Gabard B. Photostabilization of butyl methoxydibenzoylmethane (Avobenzone) and ethylhexyl methoxycinnamate by bis-ethylhexyloxyphenol methoxyphenyl triazine (Tinosorb S), a new UV broadband filterPhotochem Photobiol 2001;74:401–406. [pmid: 11594052] [doi: 10.1562/0031-8655(2001)074<0401:POBMAA>2.0.CO;2]|
|Loden M,Akerstrom U,Lindahl K,Berne B. Novel method for studying photolability of topical formulations: a case study of titanium dioxide stabilization of ketoprofenJ Pharm Sci 2005;94:781–787. [pmid: 15729703] [doi: 10.1002/jps.20295]|
The photoactive compounds in the investigated sunscreens, CAS no and SPF of the product.
|Photoactive compound||CAS no||Mainly protection against||Active ingredients in the seven investigated sunscreen products|
CAS Chemical Abstracts Service
EHMC ethylhexyl methoxycinnamate MBC 4-methylbenzylidene camphor
EHT ethylhexyl triazone OC octocrylene BMDBM butyl methoxydibenzoylmethane
BZ-3 benzophenone-3 TLDCSA terephthalylidene dicamphor sulfonic acid
TiO2titanium dioxide ZnO zinc oxide
SPF Sun Protection Factor
The dose of natural UV radiation the investigated sunscreens received
|Sunscreen||Exposure time (min)||UVA radiation (kJ/m2)||Erythemal effective radiation (J/m2)||SED|
Data from the Swedish Metrological and Hydrological Institute (SMHI)
* The exposure time for Sunscreen 7 it was 30 min, 90 min and 240 min due to technical obstacles
** Data not available due to technical obstacles at SMHI.
Summary of the AUCI values for the investigated sunscreens
|After natural UV exposure||After artificial UV exposure|
|30 min||90 min||120 min||30 min||90 min||120 min||30 min||90 min||120 min||30 min||90 min||120 min|
The AUCI is defined as AUCafter/AUCbefore. The bold numbers show when AUCI is <0.80.
* Sunscreen 7 was exposed to natural UV during 240 min.
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