| Photosensitizer-loaded magnetic nanoemulsion for use in synergic photodynamic and magnetohyperthermia therapies of neoplastic cells. | |
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MedLine Citation:
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PMID: 19198320 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study a magnetic nanoemulsion (MNE) was developed from a mixture of two components, namely biodegradable surfactants and biocompatible citrate-coated cobalt ferrite-based magnetic fluid, for entrapment of Zn(II)-Phthalocyanine (ZnPc), the latter a classical photosensitizer (PS) species used in photodynamic therapy (PDT) procedures. The sample's stability was evaluated as a function of time using photocorrelation spectroscopy (PCS) for determination of the average hydrodynamic diameter, diameter dispersion and zeta potential. The ZnPc-loaded magneto nanoemulstion (ZnPc/MNE) formulation was evaluated in vitro assays to access the phototoxicity and the effect of application of AC magnetic fields (magnetohyperthermia damage) after incubation with J774-A1 macrophages cells. Darkness toxicity, phototoxicity and AC magnetic field exposures revealed an enhancement response for combined photodynamic and magnetohyperthermia (MHT) processes, indicating the presence of the synergic effect. |
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Authors:
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Fernando L Primo; Marcilene M A Rodrigues; Andreza Ribeiro Simioni; Zulmira G M Lacava; Paulo C Morais; Antonio C Tedesco |
Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of nanoscience and nanotechnology Volume: 8 ISSN: 1533-4880 ISO Abbreviation: J Nanosci Nanotechnol Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2009-02-09 Completed Date: 2009-03-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101088195 Medline TA: J Nanosci Nanotechnol Country: United States |
Other Details:
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Languages: eng Pagination: 5873-7 Citation Subset: IM |
Affiliation:
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Departamento de Química, Laboratório de Fotobiologia e Fotomedicína, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, 14040-901, Ribeirão Preto-SP, Brasil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Line Cell Survival / drug effects Drug Carriers / chemistry* Emulsions Hyperthermia, Induced / methods* Macrophages / drug effects*, radiation effects Magnetics / methods* Materials Testing Mice Nanomedicine / methods* Nanostructures / chemistry, therapeutic use* Photochemotherapy / methods* Photosensitizing Agents / administration & dosage*, chemistry |
| Chemical | |
Reg. No./Substance:
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0/Drug Carriers; 0/Emulsions; 0/Photosensitizing Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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