Document Detail


Photosensitivity reactions to vandetanib: redevelopment after sequential treatment with docetaxel.
MedLine Citation:
PMID:  22346266     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Vandetanib (ZD6474, Zactima™) is a novel, orally available inhibitor of different intracellular signaling pathways involved in tumor growth, progression, and angiogenesis, including vascular endothelial growth factor receptor-2, epidermal growth factor receptor, and rearranged during transfection tyrosine kinase activity. The most frequently reported adverse events attributed to vandetanib include diarrhea, elevated aminotransferase, asymptomatic corrected QC interval prolongation, and hypertension. In a few randomized, double-blinded studies, cutaneous adverse events including these general symptoms have been reported, but there are only a few reports on the photosensitivity reaction to vandetanib domestically as conducted by dermatologists. In this report, we describe two cases of photosensitivity reactions induced by vandetanib. After improvement with steroid and antihistamine, the photosensitivity reaction was redeveloped by sequential treatment with docetaxel.
Authors:
Young-Min Son; Joo-Young Roh; Eun-Kyung Cho; Jong-Rok Lee
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Publication Detail:
Type:  Journal Article     Date:  2011-12-27
Journal Detail:
Title:  Annals of dermatology     Volume:  23     ISSN:  2005-3894     ISO Abbreviation:  Ann Dermatol     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2012-02-20     Completed Date:  2012-10-02     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  8916577     Medline TA:  Ann Dermatol     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  S314-8     Citation Subset:  -    
Affiliation:
Department of Dermatology, Gachon University of Medicine and Science, Gil Hospital, Incheon, Korea.
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