Document Detail


Photoresponsive Poly(S-(o-nitrobenzyl)-L-cysteine)-b-PEO from a L-Cysteine N-Carboxyanhydride Monomer: Synthesis, Self-Assembly and Phototriggered Drug-Release.
MedLine Citation:
PMID:  22519413     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A photoresponsive S-(o-nitrobenzyl)-L-cysteine N-carboxyanhydride (NBC-NCA) monomer was for the first time designed, and the related poly(S-(o-nitrobenzyl)-L-cysteine)-b-poly(ethylene glycol) (PNBC-b-PEO) block copolymers were synthesized from the ring-opening polymerization (ROP) of NBC-NCA in DMF solution at 25 oC. Their molecular structures, physical properties, photoresponsive self-assembly and drug-release of PNBC-b-PEO were thoroughly investigated. The -sheet conformational PNBC block within copolymers presented a thermotropic liquid crystal phase behavior, and the crystallinity of PEO block was progressively suppressed over the PNBC composition. The characteristic absorption peaks of these copolymers at about 310 nm and 350 nm increased over UV irradiation time, and then leveled off, indicating that the o-nitrobenzyl groups were gradually photocleaved from copolymers until the completion of photocleavage. The PNBC-b-PEO copolymers self-assembled into spherical nanoparticles in aqueous solution, presenting a photoresponsive self-assembly behavior, together with a size reduction of nanoparticles after irradiation. The anticancer drug doxorubicin can be released in a controlled manner by changing the light irradiation time, which was induced by gradually photocleaving the PNBC core of nanoparticles. This work provides a facile strategy not only for the synthesis of photoresponsive polypeptide-based block copolymers, but also for the fabrication of photoresponsive nanomedicine potential for anticancer therapy.
Authors:
Gang Liu; Chang-Ming Dong
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-20
Journal Detail:
Title:  Biomacromolecules     Volume:  -     ISSN:  1526-4602     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892849     Medline TA:  Biomacromolecules     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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