Document Detail


Photorejuvenation with topical methyl aminolevulinate and red light: a randomized, prospective, clinical, histopathologic, and morphometric study.
MedLine Citation:
PMID:  20002646     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Photodynamic therapy (PDT) is an option for skin rejuvenation. Although many studies report clinical improvement with PDT in photodamaged skin, histologic and morphometric evidence is not documented in most cases. OBJECTIVE: To evaluate clinical and histopathologic changes induced by methyl aminolevulinate (MAL)-PDT and to morphometrically quantify collagen and elastic fibers in skin remodeling induced by MAL-PDT in photodamaged skin. METHODS AND MATERIALS: Fourteen patients were treated with two sessions of MAL-PDT. The light source was a light-emitting diode: 635 nm, 37 J/cm(2). Skin biopsies were performed before and 3 and 4 months after treatment. All fragments were stained using the hematoxylin-eosin, orcein, and picrosirius techniques. Morphometric studies were done of three samples from each patient. RESULTS: Global clinical improvement was observed in 10 of 14 patients. The histopathologic study showed increased collagen fibers 3 and 6 months after treatment. The decrease in the amount of elastic fiber was statistically significant 3 (p=.016) and 6 (p=.008) months after treatment. The increase in the amount of collagen fiber was statistically significant 6 months after treatment (p=.048). CONCLUSION: Clinical improvement with regard to texture, firmness, wrinkle depth, skin coloration, and clearance of actinic keratoses was observed. Histopathologic and morphometric studies were consistent with the clinical findings.
Authors:
Maria Cl?udia Almeida Issa; Juan Pi?eiro-Maceira; Maria Teresa Campos Vieira; Beni Olej; Carlos A Mandarim-de-Lacerda; Ronir Raggio Luiz; M?nica Manela-Azulay
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2009-12-04
Journal Detail:
Title:  Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]     Volume:  36     ISSN:  1524-4725     ISO Abbreviation:  Dermatol Surg     Publication Date:  2010  
Date Detail:
Created Date:  2010-03-19     Completed Date:  2010-04-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9504371     Medline TA:  Dermatol Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  39-48     Citation Subset:  IM    
Affiliation:
Department of Internal MedicineDermatology Section, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. mariaclaudia@predialnet.com.br
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MeSH Terms
Descriptor/Qualifier:
Aminolevulinic Acid / analogs & derivatives*,  therapeutic use
Collagen
Elastic Tissue
Humans
Middle Aged
Photochemotherapy*
Photosensitizing Agents / therapeutic use*
Prospective Studies
Rejuvenation
Skin / drug effects*,  pathology*
Skin Aging / drug effects*
Chemical
Reg. No./Substance:
0/Photosensitizing Agents; 0/methyl 5-aminolevulinate; 106-60-5/Aminolevulinic Acid; 9007-34-5/Collagen
Comments/Corrections
Comment In:
Dermatol Surg. 2010;36(1):49-51   [PMID:  20002645 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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