| Photoreceptor and Post-photoreceptoral Contributions to Photopic ERG a-wave in Rhodopsin P347L Transgenic Rabbits. | |
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MedLine Citation:
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PMID: 22273723 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Purpose:The a-wave of the photopic electroretinogram (ERG) of macaque monkeys is made up of the electrical activities of cone photoreceptors and post-photoreceptoral neurons. However, it is not known whether the contributions of these two components change in retinas with inherited photoreceptor degeneration. The purpose of this study was to determine the contributions of cones and post-photoreceptoral neurons to the a-wave of the photopic ERGs in rhodopsin Pro347Leu transgenic (Tg) rabbits.Methods:Ten Tg and 10 wild-type (WT) New Zealand White rabbits were studied at 4- and 12-months-of-age. The a-waves of the photopic ERGs were elicited by xenon flashes of different stimulus strengths before and after blocking the activities of post-photoreceptoral neurons by intravitreal injections of a combination of 0.2-0.4 mM of 6-cyano-7-nitrouinoxaline-2,3(1H,4H)-dione, disodium (CNQX) and 2-4 mM of (±)-2-amino-4-phosphonobutyric acid (APB).Results:The percentage contribution of the cone photoreceptors to the photopic ERG a-waves increased with increasing stimulus strength, and the percentage ranged from 54% to 75% in 4-months-old WT rabbits. In contrast, the percentage contribution of the cone photoreceptors in 4-months-old Tg rabbits ranged from 32% to 51% (P<0.05). The mean percentage contribution of cone photoreceptors became still smaller at 11% to 48% in 12-months-old Tg rabbits.Conclusions:These results suggest that the relative contribution of cone photoreceptors to the photopic ERG a-wave is less in retinas with inherited photoreceptor degeneration. This indicates that the a-waves of the photopic ERGs in patients with retinitis pigmentosa must consider this lower contribution from the cone photoreceptors. |
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Authors:
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Rika Hirota; Mineo Kondo; Shinji Ueno; Takao Sakai; Toshiyuki Koyasu; Hiroko Terasaki |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-24 |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: - ISSN: 1552-5783 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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