Document Detail


Photoprotective potential of emulsions formulated with Buriti oil (Mauritia flexuosa) against UV irradiation on keratinocytes and fibroblasts cell lines.
MedLine Citation:
PMID:  19766688     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Considering the belief that natural lipids are safer for topical applications and that carotenoids are able to protect cells against photooxidative damage, we have investigated whether topical creams and lotions, produced with Buriti oil and commercial surfactants, can exert photoprotective effect against UVA and UVB irradiation on keratinocytes and fibroblasts. Cell treatment was divided into two steps, prior and after exposition to 30 min of UVA plus UVB radiation or to 60 min of UVA radiation. Emulsions prepared with ethoxylated fatty alcohols as surfactants and containing alpha-tocopherol caused phototoxic damage to the cells, especially when applied prior to UV exposure. Damage reported was due to prooxidant activity and phototoxic effect of the surfactant. Emulsions prepared with Sorbitan Monooleate and PEG-40 castor oil and containing panthenol as active ingredient, were able to reduce the damages caused by radiation when compared to non-treated cells. When the two cell lines used in the study were compared, keratinocytes showed an increase in cell viability higher than fibroblasts. The Buriti oil emulsions could be considered potential vehicles to transport antioxidants precursors and also be used as adjuvant in sun protection, especially in after sun formulations.
Authors:
C F Zanatta; M Mitjans; V Urgatondo; P A Rocha-Filho; M P Vinardell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-18
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  48     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  70-5     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ltd. All rights reserved.
Affiliation:
Dept Ci?ncias Farmac?uticas, Faculdade de Ci?ncias Farmac?uticas de Ribeir?o Preto, Universidade de S?o Paulo, Brazil.
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MeSH Terms
Descriptor/Qualifier:
3T3 Cells
Animals
Antioxidants / chemistry,  pharmacology
Arecaceae / chemistry*
Carotenoids / chemistry,  pharmacology*
Cell Line
Cell Survival / drug effects
Chemistry, Pharmaceutical
Emulsions
Fibroblasts / drug effects*,  radiation effects*
Humans
Indicators and Reagents
Keratinocytes / drug effects*,  radiation effects*
Mice
Plant Oils / pharmacology*
Radiation-Protective Agents / pharmacology*
Ultraviolet Rays*
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Emulsions; 0/Indicators and Reagents; 0/Plant Oils; 0/Radiation-Protective Agents; 0/buriti oil; 36-88-4/Carotenoids

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