Document Detail


Photoprotective effects of a broad-spectrum sunscreen in ultraviolet-induced cutaneous lupus erythematosus: a randomized, vehicle-controlled, double-blind study.
MedLine Citation:
PMID:  21167404     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We sought to assess if the exclusive use of a broad-spectrum sunscreen can prevent skin lesions in patients with different subtypes of cutaneous lupus erythematosus (CLE) induced by ultraviolet (UV) irradiation under standardized conditions.
METHODS: A total of 25 patients with a medical history of photosensitive CLE were included in this monocentric, randomized, vehicle-controlled, double-blind, intraindividual study. The test product and its vehicle were applied 15 minutes before UVA and UVB irradiation of uninvolved skin areas on the upper aspect of the back in a random order, and standardized phototesting was performed daily for 3 consecutive days.
RESULTS: Characteristic skin lesions were induced by UVA and UVB irradiation in 16 patients with CLE in the untreated area, and 14 patients showed a positive test result in the vehicle-treated area. In contrast, no eruptions compatible with CLE were observed in the sunscreen-treated area in any of the 25 patients. This resulted in significant differences (P < .001) between UV-irradiated sunscreen-treated versus vehicle-treated areas, and between UV-irradiated sunscreen-treated versus untreated areas. Furthermore, a significant difference (P < .05) was observed concerning the age of disease onset and the patient history of photosensitivity. Patients who were younger than 40 years at onset of CLE reported photosensitivity significantly more often than patients with a higher age of disease onset. None of the patients showed any adverse events from application of the test product or the vehicle.
LIMITATIONS: Data resulting from standardized experimental phototesting might not be transferable to a clinical setting.
CONCLUSION: These results indicate clearly that the use of a highly protective broad-spectrum sunscreen can prevent skin lesions in photosensitive patients with different subtypes of CLE.
Authors:
Annegret Kuhn; Kristina Gensch; Merle Haust; Anna-Maria Meuth; France Boyer; Patrick Dupuy; Percy Lehmann; Dieter Metze; Thomas Ruzicka
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  64     ISSN:  1097-6787     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-20     Completed Date:  2011-01-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  37-48     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
Affiliation:
Department of Dermatology, University of Muenster, Muenster, Germany. kuhnan@uni-muenster.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Confidence Intervals
Double-Blind Method
Female
Humans
Lupus Erythematosus, Cutaneous / immunology,  pathology*
Male
Middle Aged
Photosensitivity Disorders / immunology,  pathology,  prevention & control*
Reference Values
Risk Assessment
Sunscreening Agents / pharmacology*
Ultraviolet Rays / adverse effects*
Chemical
Reg. No./Substance:
0/Sunscreening Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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