Document Detail

Photoprotective action of emollients in ultraviolet therapy of psoriasis.
MedLine Citation:
PMID:  8148279     Owner:  NLM     Status:  MEDLINE    
An in vitro technique was used to measure the monochromatic protection factors of all emollients available on prescription. The action spectra for ultraviolet erythema and erythema in psoralen-sensitized skin were used to calculate, for each emollient, erythema protection factors relevant to UVB phototherapy and psoralen photochemotherapy, respectively. Of the 40 products tested, 22 (55%) had a UVB erythema protection factor > 1.2 at an application density of 2 microliters/cm2, and 31 (78%) at an application density of 4 microliters/cm2. Fewer products, 25% at 2 microliters/cm2 and 50% at 4 microliters/cm2, had a psoralen erythema protection factor > 1.2. A protection factor of 1.2 is equivalent to a reduction in ultraviolet dose of 17%, and is thus likely to be of clinical importance. These results allow a choice of emollient products which may improve response by increasing transmission of radiation through psoriasis scale without a concomitant decrease in transmission due to a sunscreening action.
M J Hudson-Peacock; B L Diffey; P M Farr
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of dermatology     Volume:  130     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-05-12     Completed Date:  1994-05-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  361-5     Citation Subset:  IM    
Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, U.K.
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MeSH Terms
Emollients / chemistry*
PUVA Therapy*
Psoriasis / therapy*
Sunscreening Agents / chemistry*
Ultraviolet Rays
Ultraviolet Therapy*
Reg. No./Substance:
0/Emollients; 0/Sunscreening Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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