Document Detail

Photophysical and photodynamical study of ellipticine: an anticancer drug molecule in bile salt modulated in vitro created liposome.
MedLine Citation:
PMID:  23059904     Owner:  NLM     Status:  Publisher    
The entrapment of anticancer drug ellipticine in the dipalmitoylphosphocholine (DPPC) liposome and its release by addition of three different bile salts, namely sodium deoxycholate, cholate and taurocholate, have been studied by steady state and time resolved fluorescence spectroscopy. We found that the release of the drug from a liposome depends on the degree of penetration of bile salts. Among the three bile salts, deoxycholate was most effective in releasing the drug from the hydrocarbon core of the liposome because of its high insertion ability owing to its maximum hydrophobicity. The time resolved studies revealed that with addition of bile salt to the liposome solution, ellipticine molecules were removed from the hydrocarbon core and were entrapped in an interfacial region of liposomes by electrostatic interaction. This led to an increase in the shorter lifetime component. On the other hand, the longer lifetime component decreased because bile salts wet the hydrocarbon core of the liposome by carrying hydrogen bonded water. Entrapment of ellipticine in the interfacial region was also supported by an increase in the rotational relaxation time with addition of bile salt.
Raina Thakur; Anupam Das; Anjan Chakraborty
Related Documents :
30784 - The relationship between guilt and quality of drug experiences.
9311924 - Addiction is a brain disease, and it matters.
3751654 - Alcohol and drug addiction in northern nigeria.
21997324 - Alcohol- and drug-involved driving in the united states: methodology for the 2007 natio...
22475524 - Olanzapine and risperidone effects on appetite and ghrelin in chronic schizophrenic pat...
21920454 - Pharmacogenomics: a new clinical or regulatory paradigm? european experiences of pharma...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-11
Journal Detail:
Title:  Physical chemistry chemical physics : PCCP     Volume:  -     ISSN:  1463-9084     ISO Abbreviation:  Phys Chem Chem Phys     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888160     Medline TA:  Phys Chem Chem Phys     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Chemistry, Indian Institute of Technology Indore, IET, M-Block, 452017, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A novel gene expression index (GEI) with software support for comparing microarray gene signatures.
Next Document:  Does MPTP intoxication in mice induce metabolite changes in the nucleus accumbens? A (1) H nuclear M...