Document Detail

Photophysical mechanism for quantum dots-induced bacterial growth inhibition.
MedLine Citation:
PMID:  19452999     Owner:  NLM     Status:  MEDLINE    
Quantum dots-induced cell growth inhibition effect and its photophysical mechanism were investigated in this report. Cell growth curve and atomic force microscopy show that QDs block cell division to inhibit the growth of bacterial cells. On the basis of combined biological and physical discoveries from cytochrome c reduction assay, hydrodynamic size, photoluminescence and UV-visible spectrometry, a photophysical mechanism involving a polypeptide or amino acid adsorption-mediated fluorescence and reactive oxygen species quenching process is proposed. The photophysical mechanism may not only provide physical insight of QDs-induced toxicity, but also render QDs potentials in antimicrobial and cancer photodynamic therapy applications.
Zhisong Lu; Chang Ming Li; Haifeng Bao; Yan Qiao; Qiaoliang Bao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of nanoscience and nanotechnology     Volume:  9     ISSN:  1533-4880     ISO Abbreviation:  J Nanosci Nanotechnol     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-20     Completed Date:  2009-06-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101088195     Medline TA:  J Nanosci Nanotechnol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3252-5     Citation Subset:  IM    
School of Chemical and Biomedical Engineering and Center for Advanced Bionanosystems, Nanyang Technological University, 70 Nanyang Drive, Singapore 637457, Singapore.
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MeSH Terms
Cytochromes c / metabolism
Escherichia coli / drug effects*,  genetics,  growth & development*
Escherichia coli Proteins / metabolism
Gene Expression Regulation, Bacterial / drug effects
Oxidation-Reduction / drug effects
Quantum Dots*
Reactive Oxygen Species / metabolism
Reg. No./Substance:
0/Escherichia coli Proteins; 0/Reactive Oxygen Species; 9007-43-6/Cytochromes c

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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