Document Detail


Photoperiod-peptide interactions in the energy intake of Siberian hamsters.
MedLine Citation:
PMID:  3562318     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Siberian hamsters (Phodopus sungorous sungorous) decrease their food intake when exposed to short ("winter-like") photoperiods. The cause of this naturally-occurring hypophagia is unknown, but it may be due to a heightened sensitivity to the factors that normally terminate food intake in long photoperiods, such as the putative satiety peptides. The purpose of the present investigation was to test whether there would be an enhanced sensitivity to the inhibitory effects of some of these peptides on food intake in short relative to long days. Ad lib-fed, adult female Siberian hamsters were housed in a long photoperiod (LD 14:10) and injected with bombesin, glucagon, cholecystokinin octapeptide (CCK-8) and calcitonin (CT). Food intake was monitored 1, 2, 4, 6, and 24 hr post-injection. Bombesin and glucagon had no effect on food intake in long day-housed hamsters. CCK-8 and CT inhibited food intake; however, CCK-8 did so without any apparent behavioral disruption, while CT produced a marked and prolonged depression of behavior. After 10 weeks of exposure to a short photoperiod (LD 8:16) the hamsters were tested again. The previously ineffective dose of bombesin greatly inhibited food intake following short photoperiod exposure. In addition, an increased inhibition of food intake by CCK-8 was also found. In contrast, glucagon did not decrease food intake and CT still produced its non-specific, behaviorally disruptive effects. To our knowledge, this is the first demonstration that the effectiveness of a putative satiety peptide can be dependent upon a change in the photoperiod.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
T J Bartness; J E Morley; A S Levine
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Peptides     Volume:  7     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:    1986 Nov-Dec
Date Detail:
Created Date:  1987-04-29     Completed Date:  1987-04-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1079-85     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight / drug effects
Bombesin / pharmacology*
Calcitonin / pharmacology*
Circadian Rhythm*
Cricetinae
Darkness
Energy Intake
Feeding Behavior* / drug effects
Female
Glucagon / pharmacology*
Light
Siberia
Sincalide / pharmacology*
Grant Support
ID/Acronym/Agency:
AM 35254/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
25126-32-3/Sincalide; 31362-50-2/Bombesin; 9007-12-9/Calcitonin; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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