Document Detail

Photomodulation of ionic current through hemithioindigo-modified gramicidin channels.
MedLine Citation:
PMID:  15455152     Owner:  NLM     Status:  MEDLINE    
Incorporation of photo-switchable amino acids into peptides and proteins offers prospects for the control of complex biochemical processes using light. Currently, only a few photo-switchable amino acids are known. We report the design and synthesis of a novel hemithioindigo-based amino acid and its incorporation into the model ion channel gramicidin. Photoisomerization of the hemithioindigo moiety between E and Z isomeric forms is shown to modulate ionic current through the channel in a predictable way. This new amino acid thus expands the possibilities for photo-control in diverse systems.
Tyler Lougheed; Vitali Borisenko; Thomas Hennig; Karola Ruck-Braun; G Andrew Woolley
Publication Detail:
Type:  Journal Article     Date:  2004-08-24
Journal Detail:
Title:  Organic & biomolecular chemistry     Volume:  2     ISSN:  1477-0520     ISO Abbreviation:  Org. Biomol. Chem.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-09-29     Completed Date:  2006-05-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101154995     Medline TA:  Org Biomol Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  2798-801     Citation Subset:  IM    
Copyright Information:
Copyright 2004 The Royal Society of Chemistry
Department of Chemistry, University of Toronto, 80 St. George St., Toronto, Ontario, Canada.
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MeSH Terms
Anti-Bacterial Agents / chemistry
Chromogenic Compounds / chemistry
Coloring Agents / chemistry
Gramicidin / chemistry*
Indoles / chemistry*
Ions / chemistry*
Models, Molecular
Molecular Structure
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Chromogenic Compounds; 0/Coloring Agents; 0/Indoles; 0/Ions; 1405-97-6/Gramicidin; 482-89-3/indigo

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